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Langendorff\u2010perfused C57BL\/6JNarl mice hearts were performed with 30\u2009minutes ischemia and 60\u2009minutes reperfusion by left anterior descending artery ligation. Before reperfusion, boiling water extracts of BC (10\u2009mg\/L) was pretreated for 15\u2009minutes. During reperfusion, BC significantly decreased the occurrence of ventricular arrhythmias by lead II electrocardiogram (ECG). Electrophysiological effect of BC was further determined in isolated ventricular myocytes by whole\u2010cell patch clamp technique. The underlying mechanism may result from its Na<jats:sup>+<\/jats:sup> channel blocking activity characterized with reduced rise slope of action potential and Na<jats:sup>+<\/jats:sup> current density. Moreover, BC dramatically reduced I\/R\u2010caused infarct size, which was accessed by 2,3,5\u2010triphenyltetrazolium chloride (TTC) assay. Since BC decreased I\/R\u2010induced myoglobin release and oxidation of Ca<jats:sup>2+<\/jats:sup>\u2010calmodulin\u2010dependent protein kinase, inhibition of myocardial necroptosis may account for the protective effects of BC on myocytes lose. This study indicated that BC may prevent I\/R induced ventricular arrhythmias and myocyte death by blocking Na<jats:sup>+<\/jats:sup> channels and decreasing necroptosis, respectively. Since most of the available antiarrhythmic remedies have unwanted adverse actions, BC could be a novel candidate for the treatment of myocardial infarction and ventricular arrhythmia.<\/jats:p>","DOI":"10.1002\/tox.22912","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T14:11:38Z","timestamp":1581775898000},"page":"774-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac protection of <i>Bauhinia championii<\/i> against reperfusion injury"],"prefix":"10.1002","volume":"35","author":[{"given":"Yun\u2010Fang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science China 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