{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:05:30Z","timestamp":1777431930595,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:00:00Z","timestamp":1584748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["17KJD330005"],"award-info":[{"award-number":["17KJD330005"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["18KJB330007"],"award-info":[{"award-number":["18KJB330007"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radon and its progeny have been classified as human class I carcinogens by the IARC. However, the mechanisms by which radon induces lung and other cancers, especially the radon\u2010induced Warburg effect, have not been fully elucidated. The aim of this study was to investigate the role of the succinate dehydrogenase subunit A (SDHA)\u2010mediated Warburg effect in (human bronchial epithelial) BEAS\u20102B cells with malignant transformations induced by long\u2010term radon exposure. Soft agar colony formation and MMP\u20109 were increased following radon\u2010induced malignant transformation. Additionally, we observed the Warburg effect in BEAS\u20102B cells following long\u2010term radon exposure, evidenced by increases in the levels of glucose uptake, lactate, and lactate dehydrogenase (LDH). Following radon exposure, the expression of SDHA was decreased, while the levels of HIF\u20101\u03b1 and hexokinase\u20102 (HK2) were increased. Our findings suggested that the SDHA\u2010associated pathway may be involved in mediating the Warburg effect in radon\u2010induced malignant transformation of BEAS\u20102B.<\/jats:p>","DOI":"10.1002\/tox.22922","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T10:35:29Z","timestamp":1584786929000},"page":"861-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SDHA\u2010mediated Warburg effect in malignantly transformed human bronchial epithelial cells following long\u2010term exposure to radon"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-531X","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Medical College Yangzhou University  Yangzhou China"},{"name":"Institute of Translational Medicine, Medical College Yangzhou University  Yangzhou 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