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The toxic impacts of the single substance have been studied extensively. However, the studies about their combined adverse impacts are not enough. In the present study, zebrafish were exposed to environmental relevant concentrations of CBZ (1, 10, and 100\u2009\u03bcg\/L), Cu (0.5, 5, and 10 \u03bcg\/L) and the mixtures (1 \u03bcg\/L CBZ\u2009+\u20090.5 \u03bcg\/L Cu, 10 \u03bcg\/L CBZ\u2009+\u20095 \u03bcg\/L Cu, 100\u2009\u03bcg\/L CBZ\u2009+\u200910 \u03bcg\/L Cu) for 45\u2009days, the effects on nervous and antioxidant systems of zebrafish were investigated. The results demonstrated that, in comparison with single exposure group, the combined presence of CBZ and Cu exacerbated the effect of antioxidant system (the ability of inhibition of hydroxyl radicals (IHR), superoxide dismutase (SOD), catalase (CAT) and glutathione S\u2010transferase (GST)) but not nervous system (Acetylcholinesterase [AChE]). The qPCR results supported the changes of corresponding enzymes activities. Hepatic histopathological analysis verified the results of biomarkers. Our work illustrated that the toxicity of mixed pollutants is very complicated, which cannot simply be inferred from the toxicity of single pollutant, and calls for more co\u2010exposure experiments to better understanding of the co\u2010effects of pollutants on aquatic organisms.<\/jats:p>","DOI":"10.1002\/tox.22945","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T17:43:27Z","timestamp":1591119807000},"page":"1091-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (<scp><i>Danio rerio<\/i><\/scp>)"],"prefix":"10.1002","volume":"35","author":[{"given":"Dantong","family":"Jia","sequence":"first","affiliation":[{"name":"School of Environmental Science and Engineering Nanjing Tech University  Nanjing PR 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