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Female mice divided into five groups; control, diazepam (2 mg\/kg), LDR (0.5Gy)\u2009+\u2009diazepam, resveratrol (20\u2009mg\/kg)\u2009+\u2009diazepam, LDR\u2009+\u2009resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro\u2010histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.<\/jats:p>","DOI":"10.1002\/tox.22949","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T13:11:40Z","timestamp":1590671500000},"page":"1137-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low dose \u03b3 radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies"],"prefix":"10.1002","volume":"35","author":[{"given":"Heba M.","family":"Karam","sequence":"first","affiliation":[{"name":"Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT) Egyptian Atomic Energy Authority (EAEA) Nasr City Cairo 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