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Current work aimed to define the cardiac defensive effects of curcumin nanoparticles (Cur Nps) against EAC induced cardiac toxicity, injury, and alterations in apoptosis, proliferation, and cytokines immunoreactivity. Forty female mice were aimlessly and equally divided into four groups [Gp1, Control; Gp2, Cur NPs; Gp3, Ehrlich ascites carcinoma (EAC); Gp4, Co\u2010treatment of EAC with Cur NPs (Cur NPs\u2009+\u2009EAC)]. Serum lactate dehydrogenase (LDH), phosphocreatine kinase (CPK), creatine kinase myoglobin (CK\u2010MB), alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), cholesterol, triglycerides, potassium ions, cardiac injury, P53, vascular endothelial growth factor protein (VEGF), Bax, and tumor necrosis factor alpha (TNF\u03b1) expressions were significantly elevated while sodium ions levels were significantly depleted in EAC when compared to control. Co\u2010treatment of EAC with Cur NPs (Cur NPs\u2009+\u2009EAC) improved these parameters as compared with EAC group. So, our results indicate that; Cur NPs induced protection to the blood and heart tissue during Ehrlich ascites carcinoma.<\/jats:p>","DOI":"10.1002\/tox.23016","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T12:39:53Z","timestamp":1598877593000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Badriyah","family":"Alotaibi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science Pharmacy College, Princess Nourah bint Abdulrahman University  Riyadh Saudi 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