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The modern treatment of cancers like chemotherapy and radiation therapy sometimes severely pounce on the basic hematopoietic stem\/progenitor cellular (HSPC) compartment which gradually disclose the clinical symptoms of MDS. The present study involves flowcytometric protein expression analysis of insulin growth factor receptor (IGFR), PI3K\u2010Akt\u2010mTOR pathway, the autophagy related proteins (ATG's), the status of antioxidative molecules SOD2 and SDF1 and apoptosis profiling in ethyl\u2010nitroso\u2010urea induced myelodysplasia. The redox status that is, reactive oxygen species was estimated with dihydroetidium and the status of mitochondria and lysosomes were checked by Janus green B and neutral red staining respectively, pre and post quercetin treatment in MDS bone marrow. The results revealed the activated IGFR\/PI3K\/Akt axis in MDS bone marrow but unconventionally both p\u2010mTOR and autophagy (p\u2010ATG1, p\u2010AT6, ATG7, ATG12) was downregulated. Interestingly, post quercetin treatment an upregulation of basal autophagocytosis, reversal of oxidative damage and proper functionality of mitochondria and lysosome was recorded. Taken together, the study hinted that the PI3K\u2010Akt\u2010mTOR pathway does not rule over the process of autophagocytosis in HSPC's of MDS bone marrow and the isoflavanoid quercetin remarkably restored autophagocytosis and hematopoietic oxidative status toward normalcy during the progression of myelodysplasia.<\/jats:p>","DOI":"10.1002\/tox.23020","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T15:42:19Z","timestamp":1601307739000},"page":"149-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quercetin induces autophagy in myelodysplastic bone marrow including hematopoietic stem\/progenitor compartment"],"prefix":"10.1002","volume":"36","author":[{"given":"Suchismita","family":"Daw","sequence":"first","affiliation":[{"name":"Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology Calcutta School of Tropical Medicine  Kolkata West 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