{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:43:01Z","timestamp":1784014981461,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular\u2010related diseases continue to be a leading cause of death globally. Among ischemic\u2010induced cardiac diseases, myocardial infarction (MI) is reported to be of an alarming value. Despite numerous improvements in the medical intrusions, still this armamentarium fails to be effective in managing the illness without setbacks. Ferruginol (FGL) is a major polyphenols and terpenoids with numerous pharmacological activities including antioxidant and anti\u2010inflammatory. Following, this work was aimed to explore the cardio protective effect of FGL (50\u2009mg\/kg) in isoprenaline hydrochloride (ISO)\u2010induced MI in experimental rats. After treatment with FGL in ISO\u2010induced MI in rats, noticeable changes were observed in the experimental rats. Injection of ISO to rats resulted in the augmented cardiac weight, serum cardiac markers (creatine kinase, creatine kinase\u2010MB, cardiac troponin T, and Cardiac troponin I), lipid peroxidation end products (thiobarbituric acid\u2010reactive substance and lipid hydroperoxides), reduced endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione), reduced ATPase activity, and escalated pro\u2010inflammatory cytokines (interleukin\u20106, tumor necrosis factor\u2010\u03b1, and nuclear factor\u2010\u03baB) levels. Interestingly, the FGL supplementation to the ISO\u2010treated rats revealed the diminished heart weight, reduced cardiac markers, and lipid peroxidation. FGL also possessed the improved antioxidants status and diminished pro\u2010inflammatory mediator levels. The outcomes of histological analysis also evidenced the cardio protective role of FGL. Treatment with FGL reduced the cardiac damage biomarkers maintained to near normal levels in ISO\u2010induced rats. These study findings disclose the prospective capability of FGL in the treatment of MI in the future.<\/jats:p>","DOI":"10.1002\/tox.23030","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T14:08:16Z","timestamp":1600438096000},"page":"249-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ameliorative effect of ferruginol on isoprenaline hydrochloride\u2010induced myocardial infarction in rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Xudong","family":"Zhang","sequence":"first","affiliation":[{"name":"Encephalopathy Center, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Wang","sequence":"additional","affiliation":[{"name":"Respiratory Department First Clinical College, Academy of Traditional Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Tonghua Traditional Chinese Medicine Hospital  Tonghua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Oncology Department Liaoyuan Second People's Hospital  Liaoyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Liaoyuan Hospital of Traditional Chinese Medicine  Liaoyuan 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