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Occupational exposure to low\u2010level ionizing radiation (&lt;1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. The present study was therefore aimed to investigate the protective impact of <jats:italic>Amphora coffaeiformis<\/jats:italic> extract and low dose gamma radiation against <jats:sc>d<\/jats:sc>\u2010GalN induced renal damage in rats. Forty\u2010eight adult male Swiss albino rats were distributed equally into eight groups. The measurements included antioxidants activities (superoxide dismutase, catalase and glutathione peroxidase) as well as lipid peroxidation level in kidney tissue. Also, kidney function tests and inflammatory markers (tumor necrosis factor alpha and nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells) were measured. Additionally, relative quantification of kidney nuclear factor erythroid 2\u2010related factor 2 (Nrf\u20102) gene was estimated. Histopathological examination was also performed in kidney tissue. The results revealed decreases in antioxidant activities and downregulation of Nrf\u20102 expression accompanied by increases in lipid peroxidation level, kidney function tests and inflammatory markers in <jats:sc>d<\/jats:sc>\u2010GaIN group. The treatment with <jats:italic>Amphora<\/jats:italic> algal extract and low dose gamma radiation ameliorated the previous measurements which were harmony with histopathological findings. In conclusion, <jats:italic>A coffaeiformis<\/jats:italic> extract and low dose gamma radiation provided marked functional and histological effects in the treating acute renal damage induced by <jats:sc>d<\/jats:sc>\u2010GalN in rats.<\/jats:p>","DOI":"10.1002\/tox.23050","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T15:01:11Z","timestamp":1603810871000},"page":"451-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amphora algae with low\u2010level ionizing radiation exposure ameliorate D\u2010galactosamine\u2010induced inflammatory impairment in rat kidney"],"prefix":"10.1002","volume":"36","author":[{"given":"Sawsan M.","family":"El\u2010sonbaty","sequence":"first","affiliation":[{"name":"Department of Radiation Microbiology National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma S. 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