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Ginsenoside Rb1 is a major bioactive ingredient of ginseng, which shows very specific anti\u2010apoptosis and anti\u2010oxidant activities. Methylglyoxal (MGO) is one of intermediate products of glucose metabolism, which is absorbed easily from high sugar foods or carbonated beverages. It may involve in a variety of detrimental processes in vivo. However, it has not been fully explored the effects of ginsenoside Rb1 on MGO\u2010induced oocytes damage. This study found that MGO\u2010induced DNA damage and mitochondrial dysfunction result in the failure of porcine oocytes maturation and low in vitro development capacity of parthenogenetic activation (PA) and in vitro fertilization (IVF) embryos. Conversely, Rb1 supplementation recovered the rate of maturation, and improved in vitro development capacity of PA and IVF embryos. Rb1 also provided porcine oocytes a lower level of reactive oxygen species production, higher level of ATP content and mitochondrial membrane potential, and stimulated pluripotency gene expression in blastocysts. The findings of this study reveal ginsenoside Rb1 protects porcine oocyte from the cytotoxicity effects of methylglyoxal and provides novel perspectives for the protection of reproduction system by functional food of ginseng.<\/jats:p>","DOI":"10.1002\/tox.23063","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T10:57:29Z","timestamp":1606301849000},"page":"586-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ginsenoside Rb1 protects porcine oocytes against methylglyoxal damage thus it improves the quality of parthenogenetic activation and in vitro fertilization embryos"],"prefix":"10.1002","volume":"36","author":[{"given":"Zhao\u2010Bo","family":"Luo","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory of Transgenic Animal and Embryo Engineering Yanbian University  Jilin 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