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Since the association between lncRNA BNIP3P1 and its cognate gene BNIP3 in preeclampsia has been revealed previously, this study aimed to further explore the function and mechanism of BNIP3P1 in preeclampsia. EdU and TUNEL assays revealed that BNIP3P1 or BNIP3 overexpression inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia. As suggested by western blot analysis, the protein levels of apoptotic markers in the cells were affected by BNIP3P1 or BNIP3 overexpression. The binding between miR\u2010128\u20103p and BNIP3P1 (or BNIP3) was explored by luciferase reporter assays. Mechanistically, BNIP3P1 bound to miR\u2010128\u20103p to upregulate BNIP3 expression by acting as a competing endogenous RNA (ceRNA). Importantly, BNIP3P1 was found to inactivate the mTOR signaling pathway. In conclusion, BNIP3P1 inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia by targeting the miR\u2010128\u20103p\/BNIP3\/mTOR signaling pathway.<\/jats:p>","DOI":"10.1002\/tox.23159","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T06:49:05Z","timestamp":1645426145000},"page":"971-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysregulated pseudogene <scp>BNIP3P1<\/scp> inhibited cell proliferation and promoted cell apoptosis in preeclampsia by acting as a competing endogenous <scp>RNA<\/scp> for <scp>BNIP3<\/scp>"],"prefix":"10.1002","volume":"37","author":[{"given":"Haoyu","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University  Huaian 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