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Magnesium lithospermate B (MLB), an active compound of <jats:italic>Salvia miltiorrhiza<\/jats:italic> (<jats:italic>Danshen<\/jats:italic>), has beneficial effects on insulin resistance and metabolic abnormalities in diet\u2010induced obese rodents. Since exposure to endocrine\u2010disrupting chemical Bisphenol A (BPA) during pregnancy mimics the effects of high fat diet\u2010induced alterations of glucose and lipid metabolism in adult male offspring, the effects of daily MLB supplementation for 4\u2009weeks on metabolic abnormalities in rats weaning from prenatal BPA\u2010exposed dams were investigated. BPA\u2010exposed rats developed obesity and adiposity concurrent with hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia, and elevation of circulating glucagon and free fatty acids. Increased hepatic fatty acid synthesis and decreased fatty acid \u03b2\u2010oxidation, activation of adipocytic adipogenesis, maturation, and lipogenesis, as well as reduction of muscular glucose uptake were demonstrated in BPA\u2010exposed rats. The aforementioned alterations were improved by MLB supplementation. Additionally, MLB displayed negative effects on glucocorticoid receptor action and inflammation, and promoted lipolysis and thermogenesis in the adipose tissues. In conclusion, our findings suggest that MLB may be a potential therapeutic compound against metabolic diseases, including maternal exposure\u2010induced metabolic abnormalities.<\/jats:p>","DOI":"10.1002\/tox.23313","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T11:33:00Z","timestamp":1624534380000},"page":"1932-1943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Magnesium lithospermate B supplementation improved prenatal Bisphenol A <scp>exposure\u2010induced<\/scp> metabolic abnormalities in male offspring"],"prefix":"10.1002","volume":"36","author":[{"given":"Wei\u2010Chi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng\u2010Ying","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of 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