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These pathophysiologic mechanisms of potassium dichromate (K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub>) have been well correlated with nephrotoxicity and cardiotoxicity. The cardioprotective and nephroprotective effects of Luteolin, a known potent antioxidant were evaluated in this study with 40 healthy rats in four experimental groups: Group A (normal saline), Groups B (30\u2009mg\/kg K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub>), Group C (Luteolin 100\u2009mg\/kg and K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub> 30\u2009mg\/kg), and Group D (Luteolin 200\u2009mg\/kg and K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub> 30\u2009mg\/kg), respectively. Markers of antioxidant defense system, oxidative stress, blood pressure and micronucleated polychromatic erythrocytes (MnPEs), immunohistochemistry of Kidney, injury molecule (Kim\u20101), nuclear factor erythroid 2\u2010related factor 2 (Nrf2), and cardiac troponin I were determined. Administration of K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub> increased blood pressure parameters in systolic, diastolic and mean arterial blood pressures, markers of oxidative stress, and frequency of micronucleated polychromatic erythrocytes, together with reduction in serum nitric oxide level. Renal Kim\u20101 and cardiac troponin I expressions were higher, but lower expressions of renal and cardiac Nrf2 were recorded with immunohistochemical analysis. Pre\u2010treatment with Luteolin restored blood pressure parameters, with concomitant reduction in oxidative stress indicators, augmented antioxidant mechanisms and serum Nitric oxide level, lowered the expressions of Kim\u20101, cardiac troponin I and up\u2010regulated of both cardiac and renal Nrf2, reduced the frequency of micronucleated polychromatic erythrocytes. Taken together, this study therefore demonstrates the cardioprotective, nephro protective and antigenotoxic effects of Luteolin through antioxidantive and radical scavenging mechanisms.<\/jats:p>","DOI":"10.1002\/tox.23329","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T05:53:17Z","timestamp":1626501197000},"page":"2146-2160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Luteolin mitigates potassium dichromate\u2010induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim\u20101\/Nrf2 signaling pathways"],"prefix":"10.1002","volume":"36","author":[{"given":"Omolola Victoria","family":"Awoyomi","sequence":"first","affiliation":[{"name":"Federal College of Animal Health and Production Technology  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemisi Dorcas","family":"Adeoye","sequence":"additional","affiliation":[{"name":"Federal College of Animal Health and Production Technology  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola Adetokunbo","family":"Oyagbemi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebunoluwa Rachael","family":"Asenuga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Benin  Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idayat Titilayo","family":"Gbadamosi","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Seun","family":"Ogunpolu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Olubunmi","family":"Falayi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasilat Oluwakemi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo Olutayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin Adetola","family":"Arojojoye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences Lead City University  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Eunice","family":"Ola\u2010Davies","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale Benard","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeolu Alex","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwafemi Omoniyi","family":"Oguntibeju","sequence":"additional","affiliation":[{"name":"Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences Cape Peninsula University of Technology  Bellville South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoh Audu","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Environmental &amp; 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