{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:50Z","timestamp":1790710610441,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polystyrene nanoparticles (PS\u2010NPs) as an issue of global environmental concern, have been shown to induce hepatic toxicity via triggering oxidative injury and inflammation. Non\u2010alcoholic fatty liver disease (NAFLD) is initiated when excessive lipid is accumulated in the liver and will proceed to liver fibrosis with repeatedly chronic liver injury. In this study, we examined whether intravenous injection of PS\u2010NPs could enhance the hepatic toxicity and potentiate the development of liver fibrosis in experimental high fat diet (HFD)\u2010induced mice. The results demonstrated that PS\u2010NPs could aggravate chronic hepatitis by interfere with liver lipid metabolism in HFD induced mice. Further, hepatic tissue in PS\u2010NPs treated HFD mice displayed substantially lowered superoxide dismutase (SOD) activity, which confirming the oxidative stress induced by PS\u2010NPs. PS\u2010NPs exposure also resulted in the up\u2010regulation of inflammation response in liver, as evidenced by the enhanced infiltration of Kupffer cells (KCs) and elevated expression of pro\u2010inflammatory related indicators. Meanwhile, Masson trichrome staining revealed that PS\u2010NPs could aggravate steatohepatitis with higher collagen fiber in HFD fed mice. Our data suggests that PS\u2010NPs can induce oxidative stress and inflammation in HDF\u2010induced experimental mice and further aggravate liver fibrosis, which highlight the potential health risks of PS\u2010NPs.<\/jats:p>","DOI":"10.1002\/tox.23404","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T13:29:49Z","timestamp":1636550989000},"page":"362-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"He","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-6442","authenticated-orcid":false,"given":"Qinglian","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23160"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036663"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0224"},{"issue":"14","key":"e_1_2_9_5_1","first-page":"1521","article-title":"Nonalcoholic fatty liver disease: a systematic review (vol 313, pg 2263, 2015)","volume":"314","author":"Rinella ME","year":"2015","journal-title":"J Am Med Assoc"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00022.2018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.040"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldg019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22674-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.02.082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.05.060"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0205"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2013.10.036"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.14020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/es400748b"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marenvres.2015.06.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519019113"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.03.051"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.136279"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b06155"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9091299"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.133794"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.116075"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b00183"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.11.070"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200004000-00002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46687"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581816653363"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.020"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b10527"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP316"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf104643b"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i8.727"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.47143"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22878"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/am300840p"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9209"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8EN00412A"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR90280A"},{"key":"e_1_2_9_40_1","article-title":"Vinyl chloride and high\u2010fat diet as a model of environment and obesity interaction","volume":"155","author":"Lang AL","year":"2020","journal-title":"J Vis Exp"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/212139"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S132304"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0414-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv115"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/es302332w"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.03.001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b03191"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22550"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02478-7"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.05.071"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111625"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.026"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601252"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.016"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.12.088"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.11.006"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.23404","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:19:50Z","timestamp":1693192790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/tox.23404"],"URL":"https:\/\/doi.org\/10.1002\/tox.23404","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,10]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}