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Puerarin is an isoflavonoid compound isolated from <jats:italic>Pueraria<\/jats:italic>, a plant used in traditional Chinese medicine. The underlying mechanisms of action of puerarin remain unclear. The objective of this study was to explore the mitigating effects of puerarin on cadmium\u2010induced oxidative damage in the bones of rats. Cadmium exposure increased oxidative damage in rat bones; this was markedly decreased by puerarin treatment, as demonstrated by changes in the activity of antioxidative enzymes. Cadmium\u2010induced blockage of the expression of key bone regulatory proteins, autophagy\u2010related markers, and signaling molecules was also alleviated by puerarin treatment. Additionally, cadmium reduced expression of the autophagic protein Rab7 and of late endosomal\/lysosomal adaptor and MAPK and mTOR activator 1 (LAMTOR1); the decrease in these proteins was not restored by puerarin treatment. We speculate that puerarin relieves the inhibition of fusion of autophagosomes with lysosomes that is induced by cadmium; however, this specific effect of puerarin and downstream effects on bone regulatory mechanisms require further investigation. In conclusion, puerarin alleviates cadmium\u2010induced oxidative damage in the bones of rats by attenuating autophagy, which is likely associated with the antioxidant activity of puerarin.<\/jats:p>","DOI":"10.1002\/tox.23437","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T12:33:07Z","timestamp":1639398787000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Puerarin alleviates cadmium\u2010induced oxidative damage to bone by reducing autophagy in rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Xishuai","family":"Tong","sequence":"first","affiliation":[{"name":"Institutes of Agricultural Science and Technology Development Joint International Research Laboratory of Agriculture and Agri\u2010Product Safety of the Ministry of Education of China, Yangzhou University  Yangzhou Jiangsu P. R. 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