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Toluene, a neurotoxin, has been widely used in various industries. However, it has a detrimental effect on the nervous system (such as hallucinations or memory impairment), while data on the mechanism underlaying its harmful effects remain limited. Therefore, this study investigates the effect of toluene on the nervous system via epigenetic and genetic changes of toluene\u2010exposed individuals. We identified significant epigenetic changes and confirmed that the affected abnormally expressed genes negatively influenced the nervous system. In particular, we confirmed that the miR\u201015 family, upregulated by toluene, downregulated <jats:italic>ABL2<\/jats:italic>, which could affect the R as signaling pathway resulting in neuronal structural abnormalities. Our study suggests that miR\u201015a\u20105p, miR\u201015b\u20105p, miR\u201016\u20105p, miR\u2010301a\u20103p, and lncRNA <jats:italic>NEAT1<\/jats:italic> may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.<\/jats:p>","DOI":"10.1002\/tox.23444","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T10:03:07Z","timestamp":1639821787000},"page":"802-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Analysis of multi\u2010omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances"],"prefix":"10.1002","volume":"37","author":[{"given":"So Yeon","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Molecular &amp; Life Science Hanyang University  Ansan South 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