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The present study aimed to illustrate the effects of Se on Cd\u2010induced heart injury. All 40 rabbits were randomly divided into four groups: control group, Se [0.5\u00a0mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u00b7body weight (BW)] group, Cd (1\u00a0mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u00b7BW) group, and Se\u2009+\u2009Cd group. After 30\u2009days of feeding, morphological changes, the levels of oxidative stress and myocardial enzyme, the content of cardiac troponin T, programmed cell death (pyroptosis, autophagy and apoptosis), and PI3K\/AKT\/PTEN transduction capacity were observed. The results showed that Cd destroyed the physiological balance of trace elements and caused myocardial damage, increased the cardiac oxidative damage and led to programmed cell death. Coadministration of Se prominently ameliorated histological lesions and improved cardiac function of hearts in Cd\u2010induced rabbits. Furthermore, Se exerted detoxification and oxidation resistance, maintained trace element homeostasis, and alleviated the changes of mRNA and protein levels of pyroptosis\u2010, autophagy\u2010 and apoptosis\u2010controlling factors and PI3K\/AKT\/PTEN signal molecules caused by Cd. In conclusion, Se might protect against Cd\u2010induced pyroptosis, autophagy and apoptosis by interfering with PI3K\/AKT\/PTEN signaling in heart.<\/jats:p>","DOI":"10.1002\/tox.23475","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T12:35:37Z","timestamp":1643632537000},"page":"1185-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Selenium protects against cadmium\u2010induced cardiac injury by attenuating programmed cell death via<scp>PI3K<\/scp>\/<scp>AKT<\/scp>\/<scp>PTEN<\/scp>signaling"],"prefix":"10.1002","volume":"37","author":[{"given":"Jiapei","family":"Feng","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huansheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Xing","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Xue","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-3879","authenticated-orcid":false,"given":"Huabin","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology Jiangxi Agricultural University Nanchang Jiangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.06.380"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-7845-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2019.109408"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-3819-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9950-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117324"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5620\/eaht.2021003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5603\/KP.2018.0022","article-title":"Parameters of platelet indices in young patients with ST elevation myocardial infarction. 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