{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:24:19Z","timestamp":1789986259544,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to air pollution has been closely associated with some cardiovascular disease. One of the mechanisms of PM<jats:sub>2.5<\/jats:sub>\u2010mediated heart injury may be to promote inflammation. We aim to investigate whether the main extract of <jats:italic>Houttuynia cordata<\/jats:italic>, 2\u2010undecanone, can prevent the inflammation caused by PM<jats:sub>2.5<\/jats:sub>, and to reveal the underlying mechanisms. The results showed that PM<jats:sub>2.5<\/jats:sub> increased the expression of certain inflammatory cytokines, and caused oxidative damage in BALB\/c mice and H9C2 cells. Supplementation with 2\u2010undecanone attenuated this PM<jats:sub>2.5<\/jats:sub>\u2010induced inflammatory injury and oxidative damage. Further, we elucidated that the protective effect of 2\u2010undecanone may be associated with NF\u2010\u03baB and Nrf2\/HO\u20101 pathways. The NF\u2010\u03baB pathway was distinctly activated after treated by PM<jats:sub>2.5<\/jats:sub>, which can be blocked by 2\u2010undecanone, accompanied by increasing Nrf2 and HO\u20101 levels. To figure out the relationship between NF\u2010\u03baB and Nrf2\/HO\u20101 pathways, we knocked down Nrf2 gene. NF\u2010\u03baB pathway proteins and downstream inflammatory cytokines were significantly increased after treatment with PM<jats:sub>2.5<\/jats:sub>, while 2\u2010undecanone could decrease expression of these proteins. In conclusion, it is possible that 2\u2010undecanone can induce the expression of the antioxidant enzyme HO\u20101 by activating Nrf2, thereby reducing NF\u2010\u03baB pathway and inflammatory damage of mouse myocardium caused by PM<jats:sub>2.5<\/jats:sub> exposure.<\/jats:p>","DOI":"10.1002\/tox.23513","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T09:17:02Z","timestamp":1647249422000},"page":"1642-1652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>2\u2010undecanone<\/scp> protects against fine particles\u2010induced heart inflammation via modulating Nrf2\/<scp>HO<\/scp>\u20101 and <scp>NF\u2010\u03baB<\/scp> pathways"],"prefix":"10.1002","volume":"37","author":[{"given":"Yuhang","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Food Nutrition and Safety Dalian Medical University  Dalian 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