{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:21:24Z","timestamp":1791598884246,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073575"],"award-info":[{"award-number":["82073575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bisphenol A (BPA)'s immunotoxic properties have received increasing interest, which can lead to immune dysfunction and related disease development. However, the mechanism is not completely clear. A growing body of evidence suggests that autophagy has important roles in innate immunity, inflammatory response, and adaptive immunity. This study aimed to investigate the possible mechanisms of mammalian target of rapamycin (mTOR), aryl hydrocarbon receptor (AhR), and autophagy in Treg\/Th17 imbalance induced by perinatal BPA exposure. Our results showed that the number of Th17 cells in the spleen of offspring female mice significantly increased, while the number of Treg cells decreased significantly, which was consistent with the expression levels of up\u2010regulation of ROR\u03b3t protein and a down\u2010regulation Foxp3 protein. The levels of mTOR, p\u2010mTOR, P62, and AhR protein expression increased, and LC3 protein decreased in spleen. However, in the thymus, we found that ROR\u03b3t and Foxp3 proteins changed most significantly in the low\u2010dose BPA group, and the same as p\u2010mTOR and P62 protein levels. We conjectured that the potential mechanism of the imbalance of Th17\/Treg upon perinatal exposure to BPA was probably associated with autophagy dysfunction. Proper autophagy plays an important role in maintaining the homeostasis of the thymic and spleen immune system.<\/jats:p>","DOI":"10.1002\/tox.23525","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:30:03Z","timestamp":1648733403000},"page":"1781-1789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of mammalian target of rapamycin and aryl hydrocarbon receptor\u2010mediating autophagy signaling on the balance of Th17\/Treg cells during perinatal bisphenol A\u00a0exposure in female offspring mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Liang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Health, School of Public Health China Medical University  Shenyang Liaoning China"},{"name":"School of Public Health Jinzhou medical university  Jinzhou Liaoning 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