{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:05:55Z","timestamp":1790859955508,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To explore the therapeutic value of lupeol on collagen\u2010induced arthritis (CIA) in rats, a rheumatoid arthritis model. Lupeol is well known pentacyclic triterpene found in various plant sources, which possess anti\u2010inflammatory and antioxidant actions. The current study was assessed the anti\u2010arthritic potential of lupeol and its molecular mechanisms as compared with indomethacin (Indo) in collagen\u2010induced arthritis CIA rats. The rats were randomly alienated into five groups: Control, CIA alone, CIA\u2009+\u2009lupeol (10\u00a0mg\/kg bw), CIA\u2009+\u2009Indomethacin (3\u00a0mg\/kg bw), and lupeol (10\u00a0mg\/kg bw) alone. The paw volume, biochemical, hematological parameters, inflammatory enzymes, and cytokines were measured. As well protein expression of apoptotic proteins, and histopathological of ankle joint were examined. Inflammatory markers, cytokines, histological changes, paw volume, and inflammation were intensely reduced and enhanced apoptosis by lupeol. Alterations in hematological parameters, rheumatoid factor, C\u2010reactive protein, and ceruloplasmin in arthritis were reverted by lupeol. Protein expressions of Bcl\u20102, and P13K\/Akt signaling were declined, whereas the Bax, caspssae\u20103, and caspase\u20109 were elevated. These results highlighted that lupeol suppresses P13K\/Akt signaling and has a promising anti\u2010arthritic potential for collagen\u2010induced rheumatic arthritis treatment. Hence lupeol would be suggested as an alternative natural source with potent anti\u2010inflammatory and apoptotic actions for chronic inflammatory disorders.<\/jats:p>","DOI":"10.1002\/tox.23529","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T14:09:15Z","timestamp":1650550155000},"page":"1814-1822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of lupeol on arthritis induced by type <scp>II<\/scp> collagen via the suppression of <scp>P13K<\/scp>\/<scp>AKT<\/scp> signaling pathway in <i>Sprague dawley<\/i> rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Tiebing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Trauma Joint Ward 1 Xi'an Hospital of Traditional Chinese Medicine  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Surgery People's Liberation Army  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamalai","family":"Vijayalakshmi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Rabiammal Ahamed Maideen College for Women  Thiruvarur Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-1111","authenticated-orcid":false,"given":"Bin","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Second Bone Injury Shaanxi Provincial Hospital of Traditional Chinese Medicine  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100161"},{"issue":"8","key":"e_1_2_8_4_1","first-page":"2258","article-title":"Prevalence of metabolic syndrome in women with rheumatoid arthritis and effective factors","volume":"7","author":"Bilecik NA","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.397"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.25135\/rnp.15.17.05.100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02154-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20864"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103952"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-1065-x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01570.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470856734.ch5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12754"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2017.041"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.04.033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.01.047"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110559"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2014.38"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815588612"},{"key":"e_1_2_8_21_1","unstructured":"J Biol Chem 112 Estimation of haemoglobin"},{"key":"e_1_2_8_22_1","volume-title":"Laboratory manual of rural tropical hospitals: a basis for training courses","author":"Chebrough M"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4746.1496"},{"key":"e_1_2_8_24_1","first-page":"161","article-title":"An improved colorimetric enzymatic assay of ceruloplasmin","volume":"58","author":"Ravin HA","year":"1961","journal-title":"J Lab Clin Med"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.10.004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2667"},{"key":"e_1_2_8_28_1","first-page":"877","article-title":"Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats","volume":"26","author":"Begum VH","year":"1988","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)94909-Z"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52071.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01969985"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.2.174"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2015.08.007"},{"issue":"27","key":"e_1_2_8_36_1","first-page":"1232816","article-title":"Lupeol counteracts the ProinflammatorySignalling triggered in macrophages by 7\u2010Keto\u2010cholesterol: new perspectives in the therapy of atherosclerosis","volume":"2020","author":"Saha S","year":"2020","journal-title":"Oxidative Med Cell Longev"},{"key":"e_1_2_8_37_1","first-page":"281","article-title":"A review on the potential uses of ferns","volume":"12","author":"Mannan MM","year":"2008","journal-title":"Ethnobot Leaflets"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-019-0090-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00077-4"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-64"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15475.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.02.010"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0746-4"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0309-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533034615609014"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.23529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:56:19Z","timestamp":1692838579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/tox.23529"],"URL":"https:\/\/doi.org\/10.1002\/tox.23529","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,21]]},"assertion":[{"value":"2021-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}