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Hyperglycemia associated advanced glycation end\u2010products (AGEs) increase tubular epithelial\u2010myofibroblast transdifferentiation (TEMT) and extracellular matrix synthesis and thereby causes renal fibrosis. The chalcone isoliquiritigenin, found in many herbs of <jats:italic>Glycyrrhiza<\/jats:italic> family, is known for potential health\u2010promoting effects. However, their effects on AGE\u2010associated renal proximal tubular fibrosis are not known yet. In this study, the effect of isoliquiritigenin on AGE\u2010induced renal proximal tubular fibrosis was determined in cultured HK\u20102 cell line. The results show that 200\u2009\u03bcg\/mL of AGE\u2010induced TEMT and the formed myofibroblasts synthesized collagen to increase extracellular matrix formation thereby lead to renal tubular fibrosis. However, treatment with 200\u2009nM of isoliquiritigenin considerably inhibited the TEMT and suppressed the TGF\u03b2\/STAT3 mechanism to inhibit collagen secretion. Therefore, isoliquiritigenin effectively suppressed AGE\u2010induced renal tubular fibrosis.<\/jats:p>","DOI":"10.1002\/tox.23553","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T10:50:31Z","timestamp":1652871031000},"page":"2096-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Isoliquiritigenin ameliorates advanced glycation end\u2010products toxicity on renal proximal tubular epithelial cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Chin\u2010Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Ph.D. Program for Aging  Taichung Taiwan"},{"name":"Department of Chinese Medicine Yuan Sheng Hospital  Chang Hua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung Shan Medical University Hospital  Taichung 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