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Syringic acid (SA), a natural polyphenolic compound has potential antioxidant, anti\u2010inflammatory and several beneficial effects. Therefore, in this study, we evaluated hepatoprotective effect of SA against SV\u2010induced liver injury in rats. Wistar rats were treated with SV orally at a dose of 500\u2009mg\/kg, once daily, for 14\u2009days. Another three groups of rats were administered with SV and concurrently treated with SA (40 and 80\u2009mg\/kg) and silymarin (SIL) (100\u2009mg\/kg) for 14\u2009days. SV administration for 14\u2009days caused significant <jats:italic>(p<\/jats:italic>\u2009&lt;\u2009.001) elevation of liver transaminases and ALP in serum. Liver MDA level was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) increased with a concomitant decrease (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in enzymic antioxidants activities in SV administered rats. SV administration also caused the upregulation of proinflammatory markers such as tumor necrosis factor \u03b1, c\u2010Jun N\u2010terminal kinase, nuclear factor kappa B, cyclooxygenase\u20102 and Interleukin 6 expressions in liver tissue. Histopathological studies also revealed the presence of inflammatory cell infiltration and hepatocellular necrosis upon SV administration. At both doses, concurrent administration of SA and SIL significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) inhibited the liver transaminase activities in serum, oxidative stress, and proinflammatory markers expression in liver tissue. Our current results suggest that SA can be a promising herbal drug that can inhibit SV\u2010induced hepatotoxicity when administered together due its potential anti\u2010inflammatory effects.<\/jats:p>","DOI":"10.1002\/tox.23557","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:24:02Z","timestamp":1652264642000},"page":"2143-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Syringic acid and silymarin concurrent administration inhibits sodium valproate\u2010induced liver injury in rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Sukumaran","family":"Gheena","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences  Chennai Tamil Nadu India"},{"name":"Department of Pharmacology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences  Chennai Tamil 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