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The goal of this study was to investigate if Avena sativa (AVS) extract could ameliorate Ag NPs toxicity\u2010induced alterations in liver structure and function, DNA damage, apoptosis, and oxidative stress. Twenty adult male rats were assigned randomly to four groups: control, AVS (intragastrically, 5\u00a0g\/Kg body weight\/day) for 2\u2009weeks, Ag NPs (400\u2009mg\/kg body weight\/day) for 1\u2009week as acute toxicity and Ag NPs\u2009+\u2009AVS (same therapy of Ag NPs as acute toxicity with AVS). This study demonstrated a statistical significant increase in serum levels of liver function tests (AST, ALT, ALP and globulin), liver DNA damage, apoptotic P53 and Malondialdehyde after Ag NPs administration when compared to control group. Conversely, statistical significant decreases were detected in serum albumin, total proteins, liver reduced glutathione, catalase, superoxide dismutase, glutathione S\u2010transferase and anti\u2010apoptotic Bcl<jats:sub>2<\/jats:sub> in Ag NPs group as compared to control group. Interestingly, treatment of Ag NPs with AVS (Ag Nps\u2009+\u2009AVS) was associated with significant improvements of the studied parameters, liver structure and functions. Avena sativa (AVS) extract could scavenge free radicals producing beneficial effects against acute Ag NPs hepatotoxicity in rats induced through activation of oxidative stress and apoptosis.<\/jats:p>","DOI":"10.1002\/tox.23606","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T05:09:01Z","timestamp":1656479341000},"page":"2412-2418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The potential curative role of <scp>Avena<\/scp> sativa extract against oxidative stress, <scp>DNA<\/scp> damage and apoptosis induced by acute hepatotoxicity of silver nanoparticles in rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-3603","authenticated-orcid":false,"given":"Ehab","family":"Tousson","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Science Tanta University  Tanta 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