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Ferroptosis is a novel iron\u2010dependent form of regulated cell death that is closely associated with the accumulation of lipid peroxides, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and reactive oxygen species (ROS). In this study, we found that 1,3\u2010DCP could induce mouse liver injury via ferroptosis. Administrating of C57BL\/6J mice with 12.5, 25, and 50\u2009mg\/kg 1,3\u2010DCP for 4\u2009weeks via oral gavage, the data showed that 1,3\u2010DCP exposure led to the pathological changes in mouse livers, remarkably induced accumulation of malondialdehyde (MDA) and Iron, reduction of glutathione (GSH), and changed in the expression of ferroptosis marker proteins glutathione peroxidase 4 (GPX4) and acyl\u2010CoA synthetase\u20104 (ACSL4). Then, we also proved the results with HepG2 cells in vitro. The data showed that treatment 1,3\u2010DCP significantly triggered the ferroptosis in vitro\n                    <jats:italic>.<\/jats:italic>\n                    Furthermore, we found that the ferroptosis\u2010related signal pathways were significantly activated in mice livers and HepG2 cells in response to 1,3\u2010DCP exposure. The data showed that 1,3\u2010DCP induced ferroptosis by inhibiting nuclear factor erythroid 2\u2010related factor 2 (Nrf2) translocation into nuclear and thereby suppressing the expression of its downstream target proteins including GPX4, ferritin heavy chain (FTH), ferroportin (FPN), cystine\/glutamate transporter xCT (SLC7A11), and heme oxygenase 1 (HO\u20101). Taken together, our findings confirmed that 1,3\u2010DCP induced ferroptosis via the Nrf2\/ARE signaling pathway in hepatocytes. Our works provide new toxicity mechanisms of 1,3\u2010DCP with ferroptosis on hepatocytes injury.\n                  <\/jats:p>","DOI":"10.1002\/tox.23615","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T11:13:42Z","timestamp":1658574822000},"page":"2515-2528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["1,3\u2010Dichloro\u20102\u2010propanol induced ferroptosis through Nrf2\/\n                    <scp>ARE<\/scp>\n                    signaling pathway in hepatocytes"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-167X","authenticated-orcid":false,"given":"Shuang","family":"Guan","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Jilin University  Changchun People's Republic of China"},{"name":"Key Laboratory of Zoonosis, Ministry of Education College of Veterinary Medicine Jilin University  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