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Many studies revealed that Pb could adversely affect several organs, including the male reproductive system. Pb\u2010induced reproductive toxicity could lead to infertility. Thus, finding safe and clinically applicable protective agents against this complication is important. It has been found that oxidative stress plays a fundamental role in the pathogenesis of Pb\u2010induced reprotoxicity. Glycine is the simplest amino acid with a wide range of pharmacological activities. It has been found that glycine could attenuate oxidative stress and mitochondrial impairment in various experimental models. The current study was designed to evaluate the role of glycine in Pb\u2010induced reproductive toxicity in male mice. Male BALB\/c mice received Pb (20\u2009mg\/kg\/day; gavage; 35 consecutive days) and treated with glycine (250 and 500\u2009mg\/kg\/day; gavage; 35 consecutive days). Then, reproductive system weight indices, biomarkers of oxidative stress in the testis and isolated sperm, sperm kinetic, sperm mitochondrial indices, and testis histopathological alterations were monitored. A significant change in testis, epididymis, and Vas deferens weight was evident in Pb\u2010treated animals. Markers of oxidative stress were also significantly increased in the testis and isolated sperm of the Pb\u2010treated group. A significant disruption in sperm kinetic was also evident when mice received Pb. Moreover, Pb exposure caused significant deterioration in sperm mitochondrial indices. Tubular injury, tubular desquamation, and decreased spermatogenic index were histopathological alterations detected in Pb\u2010treated mice. It was found that glycine significantly blunted oxidative stress markers in testis and sperm, improved sperm mitochondrial parameters, causing considerable higher velocity\u2010related indices (VSL, VCL, and VAP) and percentages of progressively motile sperm, and decreased testis histopathological changes in Pb\u2010exposed animals. These data suggest glycine as a potential protective agent against Pb\u2010induced reproductive toxicity. The effects of glycine on oxidative stress markers and mitochondrial function play a key role in its protective mechanism.<\/jats:p>","DOI":"10.1002\/tox.23654","type":"journal-article","created":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T09:40:15Z","timestamp":1662889215000},"page":"2990-3006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["RETRACTED: Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving\u00a0kinematics of sperm, and blunting the downregulation of enzymes involved in the steroidogenesis"],"prefix":"10.1002","volume":"37","author":[{"given":"Mohammad Mehdi","family":"Ommati","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"},{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences  Shiraz 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