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Sprague\u2010Dawley rats were administered by gavage with different concentrations of vitamin B complex once a day for 28\u2009days, and then by intratracheal instillation with saline or PM<jats:sub>2.5<\/jats:sub> once every 2\u2009days for three times. Vitamin B continued to be taken during the PM<jats:sub>2.5<\/jats:sub> exposure. Rats were sacrificed 24\u2009h after the last exposure. The results showed that vitamin B complex could block the pathological changes and injury in lungs induced by PM<jats:sub>2.5<\/jats:sub>. Meanwhile, vitamin B complex could prevent the abnormal DNA methylation of IL\u20104 and IFN\u2010\u03b3 to antagonize the imbalance of IL\u20104\/IFN\u2010\u03b3 associated with inflammation. It was further found that vitamin B complex could regulate DNA methyltransferases (DNMTs) and increase the S\u2010adenosylmethionine (SAM)\/S\u2010Adenosyl\u2010L\u2010homocysteine (SAH) ratio to reverse the hypomethylation of genomic DNA and the abnormal DNA methylation of IL\u20104 and IFN\u2010\u03b3. In conclusion, vitamin B complex has a protective effect on acute lung injury by attenuating abnormal DNA methylation induced by PM<jats:sub>2.5<\/jats:sub> in rats. This study may provide a new insight into the physiological function of vitamin B to prevent the health effects induced by PM<jats:sub>2.5<\/jats:sub>.<\/jats:p>","DOI":"10.1002\/tox.23689","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T17:49:26Z","timestamp":1666720166000},"page":"403-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin B complex blocks the dust fall <scp>PM<sub>2<\/sub><\/scp><sub>.5<\/sub>\u2010induced acute lung injury through <scp>DNA<\/scp> methylation in rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-6560","authenticated-orcid":false,"given":"Jun","family":"Bai","sequence":"first","affiliation":[{"name":"School of Public Health Southwest Medical University  Luzhou 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