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One such cancer is the oral squamous cell carcinoma (OSCC), which requires new therapeutic strategies. <jats:italic>Ficus septica<\/jats:italic> extract has been used in traditional medicine to treat infectious diseases. In this study, we examined the anti\u2010proliferative effects of an extract of <jats:italic>F. septica<\/jats:italic> bark (FSB) in OSCC cells. Our results showed that FSB caused a concentration\u2010dependent reduction in the viability of SCC2095 OSCC cells, as determined by 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide assays, and was less sensitive to fibroblasts. In addition, FSB induced apoptosis by activating caspases, accompanied by the modulation of Akt\/mTOR\/NF\u2010\u03baB and mitogen\u2010activated protein kinase signaling. Moreover, FSB increased reactive oxygen species generation in a concentration\u2010dependent manner in SCC2095 cells. Furthermore, FSB inhibited cell migration and modulated the levels of the cell adhesion molecules including E\u2010cadherin, N\u2010cadherin, and Snail in SCC2095 cells. Pinoresinol, a lignan isolated from FSB, showed antitumor effects in SCC2095 cells, implying that this compound might play an important role in FSB\u2010induced OSCC cell death. Taken together, FSB is a potential anti\u2010tumor agent against OSCC cells.<\/jats:p>","DOI":"10.1002\/tox.23716","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T20:31:04Z","timestamp":1669581064000},"page":"666-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Extract of <scp><i>Ficus septica<\/i><\/scp> modulates apoptosis and migration in human oral squamous cell carcinoma cells"],"prefix":"10.1002","volume":"38","author":[{"given":"Li\u2010Yuan","family":"Bai","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-6788","authenticated-orcid":false,"given":"Kay Li\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Translational Research in Biomedicine Kaohsiung Chang\u2010Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Fang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"Cancer Center China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Chu","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kinmen Hospital Ministry of Health and Welfare  Kinmen Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Lan","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-1353","authenticated-orcid":false,"given":"Bo\u2010Rong","family":"Peng","sequence":"additional","affiliation":[{"name":"Doctoral Degree Program in Marine Biotechnology National Sun Yat\u2010sen University  Kaohsiung Taiwan"},{"name":"National Museum of Marine Biology &amp; 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