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It is a known carcinogen that alters cell cycle disruption and cell proliferation. However, its chemical mechanism remain a mystery. Circular RNAs (circRNAs) are a subtype of noncoding RNAs (ncRNAs) that play a variety of roles in biological processes. Hsa_circ_001944 expression was upregulated in 30 leukemia patients and HQ\u2010induced malignant transformed TK6 cells. Hsa_circ_001944 silencing inhibited the growth of HQ\u2010TK6 cells and halted the cell cycle. The silencing of hsa_circ_0001944 led to increased cell accumulation in G1 versus S phase, increased apoptosis in the sh1944 versus the shNC group, and increased levels of DNA damage (\u03b3\u2010H2AX), leading to cell cycle arrest. In summary, inhibition of hsa_circ_001944 restricted cell growth by inhibiting cell cycle arrest and induced growth of HQ\u2010TK6 cells by modulating PARP1 expression. Hsa_circ_0001944 targeted HuR, which is a kind of RNA\u2010binding protein, to control PARP1 expression via RNAinter, RBPmap, and RBPdb. Fluorescence in situ hybridization combined with immunofluorescent labeling and western blotting experiments showed that hsa_circ_001944 was able to dissociate HuR and PARP1 binding in HQ\u2010TK6 cells, control PARP1 production, and ultimately alter the PARP1\/H\u2010Ras pathway.<\/jats:p>","DOI":"10.1002\/tox.23719","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T09:38:00Z","timestamp":1669801080000},"page":"381-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hsa_circ_0001944 regulates apoptosis by regulating the binding of <scp>PARP1<\/scp> and <scp>HuR<\/scp> in leukemia and malignant transformed cells induced by hydroquinone"],"prefix":"10.1002","volume":"38","author":[{"given":"Bohuan","family":"Zhong","sequence":"first","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan 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