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Male BALB\/c mice and alpha mouse liver 12 (AML\u201012) cells were used in this paper. The results showed that AML\u201012 cells treated with naringin significantly reduced cell injury, reactive oxygen species release and apoptosis level; Moreover, naringin notably alleviated liver injury by decreasing aspartate transaminase, alanine transaminase and malondialdehyde, and increasing superoxide dismutase, glutathione and catalase levels. Mechanism researches indicated that naringin increased the expression levels of sirtuin 1 (SIRT1), and inhibited the downstream inflammatory, apoptotic and oxidative stress signaling pathways. Further validation was obtained by knocking down SIRT1 in vitro, which proved the effects of naringin on doxorubicin\u2010induced liver injury. Therefore, naringin is a valuable lead compound for preventing doxorubicin\u2010induced liver damage by reducing oxidative stress, inflammation, and apoptosis via up\u2010regulation of SIRT1.<\/jats:p>","DOI":"10.1002\/tox.23755","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T08:37:55Z","timestamp":1677055075000},"page":"1153-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Naringin against\n                    <scp>doxorubicin\u2010induced<\/scp>\n                    hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up\u2010regulation of\n                    <scp>SIRT1<\/scp>"],"prefix":"10.1002","volume":"38","author":[{"given":"Yan","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Pharmacy First Affiliated Hospital of Dalian Medical University  Dalian 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