{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:55:33Z","timestamp":1785902133665,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nickel (Ni) is an important and widely hazardous chemical industrial waste. Excessive Ni exposure could cause multi\u2010organs toxicity in human and animals. Liver is the major target organ of Ni accumulation and toxicity, however, the precise mechanism is still unclear. In this study, nickel chloride (NiCl\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010treatment induced hepatic histopathological changes in the mice, and, transmission electron microscopy results showed mitochondrial swollen and deformed of hepatocyte. Next, the mitochondrial damages including mitochondrial biogenesis, mitochondrial dynamics, and mitophagy were measured after NiCl\n                    <jats:sub>2<\/jats:sub>\n                    administration. The results showed that NiCl\n                    <jats:sub>2<\/jats:sub>\n                    suppressed mitochondrial biogenesis by decreasing PGC\u20101\u03b1, TFAM, and NRF1 protein and mRNA expression levels. Meanwhile, the proteins involved in mitochondrial fusion were reduced by NiCl\n                    <jats:sub>2<\/jats:sub>\n                    , such as Mfn1 and Mfn2, however, mitochondrial fission proteins Drip1 and Fis1 were significantly increased. The up\u2010regulation of mitochondrial p62 and LC3II expression indicated that NiCl\n                    <jats:sub>2<\/jats:sub>\n                    increased mitophagy in the liver. Moreover, the receptor\u2010mediated mitophagy and ubiquitin (Ub)\u2010dependent mitophagy were detected. NiCl\n                    <jats:sub>2<\/jats:sub>\n                    promoted PINK1 accumulation and Parkin recruitment on mitochondria. And, the receptor proteins of mitophagy Bnip3 and FUNDC1 were increased in the NiCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010treated mice liver. Overall, these results show that NiCl\n                    <jats:sub>2<\/jats:sub>\n                    could induce mitochondria damage in the liver of mice, and, dysfunction of mitochondrial biogenesis, mitochondrial dynamics and mitophagy involved in the molecular mechanism of NiCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced hepatotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/tox.23758","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T04:51:34Z","timestamp":1676523094000},"page":"1185-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Nickel induces hepatotoxicity by mitochondrial biogenesis, mitochondrial dynamics, and mitophagy dysfunction"],"prefix":"10.1002","volume":"38","author":[{"given":"Hongrui","family":"Guo","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Sichuan Agricultural University  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