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The present study investigated the protective effects of carvacrol (CAR) against testicular toxicity induced by sodium arsenite (SA). Rats were given SA (10\u00a0mg\/kg) and\/or CAR (25 or 50\u2009mg\/kg) for 14\u2009days. Semen analyzes showed that CAR increased sperm motility and decreased the percentage of abnormal and dead sperm. It was determined that the oxidative stress induced by SA decreased with the increase of Nrf\u20102 and HO\u20101 expressions, SOD, CAT, GPx, and GSH levels, and MDA levels decreased after CAR treatment. It was observed that autophagy and inflammation triggered by SA in testicular tissue were alleviated by suppressing the expressions of LC3A, LC3B, MAPK\u201014, NF\u2010\u03baB, TNF\u2010\u03b1, IL\u20101\u03b2, iNOS, and COX\u20102 biomarkers in rats given CAR. Also, CAR treatment suppressed SA\u2010induced apoptosis by inhibiting Bax and Caspase\u20103 expressions in testicles and up\u2010regulating Bcl\u20102 expression. Histopathological analyzes showed that rats given SA had deterioration in tubule structure and spermatogenesis cell line, especially a serious loss of spermatogonia cells, atrophy of seminiferous tubules, and deterioration of germinal epithelium. In the group given CAR, the germinal epithelium and connective tissue were in normal morphological structure and an increase in seminiferous tubule diameters was observed. As a result, it was determined that oxidative stress, inflammation, autophagy, and apoptosis induced by SA were suppressed by CAR, thus protecting the testicular tissue from damage and increasing semen quality.<\/jats:p>","DOI":"10.1002\/tox.23762","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T02:50:48Z","timestamp":1678157448000},"page":"1265-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite\u2010induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7858","authenticated-orcid":false,"given":"Cihan","family":"Gur","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Biochemistry Atat\u00fcrk University  Erzurum 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