{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:36:50Z","timestamp":1771457810814,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170753"],"award-info":[{"award-number":["82170753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nephrotoxicity is a major side effect of cisplatin. Apoptosis, oxidative stress, inflammation, and the MAPK signaling pathway activation are concerned with the pathophysiology of cisplatin\u2010induced acute kidney injury (AKI). Madecassoside (MA), an active constituent of\n                    <jats:italic>Centella asiatica<\/jats:italic>\n                    , has anti\u2010oxidative and anti\u2010inflammatory effects. The present research aim to investigate the underlying protective mechanisms of MA on cisplatin nephrotoxicity. Pretreatment of mice with MA markedly ameliorated cisplatin\u2010induced renal tubular cell injury evidenced by the improvement of kidney function and kidney morphology and blocked upregulation of kidney injury biomarkers (kidney injury molecule 1 (KIM\u20101) and neutrophil gelatinase\u2010associated lipocalin (NGAL)). Cisplatin\u2010induced renal cell apoptosis, inflammation, and oxidative stress were also prevented by MA treatment. Consistent with the in vivo results, MA pretreatment attenuated cisplatin\u2010induced renal cell apoptosis, oxidative stress, and inflammation. Transcriptome analysis using RNA\u2010sequencing suggested that the MAPK signaling pathway was the most affected, and MA could inhibit cisplatin\u2010induced MAPK signaling pathway activation in vivo and in vitro. In summary, MA treatment ameliorated cisplatin\u2010induced renal tubular damage possibly by decreasing activation of the MAPK signaling pathway, suggesting its potential for the treatment of AKI.\n                  <\/jats:p>","DOI":"10.1002\/tox.23777","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T14:59:20Z","timestamp":1682261960000},"page":"1473-1483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Madecassoside ameliorates cisplatin\u2010induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway"],"prefix":"10.1002","volume":"38","author":[{"given":"Hui","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Children's Health Care, The First Affiliated Hospital of Nanjing Medical University Jiangsu Maternal and Child Health Care Hospital  Nanjing 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