{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:12:54Z","timestamp":1791976374652,"version":"4.4.0"},"reference-count":79,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03bb\u2010Cyhalothrin, a type II synthetic pyrethroid, has been widely used in households, agriculture, public health, and gardening to control insect pests. Despite its widespread usage, it is known to induce a variety of adverse effects, including hepatotoxicity and nephrotoxicity. The goal of this study was to investigate the protective effect of carvacrol, which has antioxidant, anti\u2010inflammatory, anti\u2010apoptotic, and some other properties, on \u03bb\u2010Cyhalothrin\u2010induced hepatotoxicity and nephrotoxicity 35 male Sprague\u2013Dawley rats were randomly divided into five groups for this purpose: I\u2010Control group: II\u2010CRV group (50\u2009mg\/kg carvacrol), III\u2010LCT group (6.23\u2009mg\/kg LCT), IV\u2010LCT\u2009+\u2009CRV 25 group (6.23\u2009mg\/kg LCT\u2009+\u200925\u2009mg\/kg carvacrol), and V\u2010LCT\u2009+\u2009CRV 50 group (6.23\u2009mg\/kg LCT\u2009+\u200950\u2009mg\/kg carvacrol). Using biochemical, real\u2010time PCR, and western blotting methods, the collected tissues were analyzed. While \u03bb\u2010Cyhalothrin treatment increased MDA levels, which are indicated of lipid peroxidation, but reduced SOD, CAT, GPx activities, and GSH levels. After receiving carvacrol therapy, the degree of oxidative stress reduced as the values of these parameters approached those of the control group. Increased inflammation, apoptosis, endoplasmic reticulum stress, and autophagy with \u03bb\u2010Cyhalothrin administration reduced with carvacrol co\u2010administration, and liver and kidney tissues were protected from damage, depending on the degree of oxidative stress. After considering all of these data, it was discovered that \u03bb\u2010Cyhalothrin\u2010induced oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy in the liver and kidneys; however, carvacrol protected the tissues from damage. Our findings indicate that carvacrol may be a promising protective agent in \u03bb\u2010Cyhalothrin\u2010induced hepatotoxicity and nephrotoxicity.<\/jats:p>","DOI":"10.1002\/tox.23784","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T13:10:12Z","timestamp":1679490612000},"page":"1535-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Carvacrol protects against\n                    <scp>\u03bb\u2010<\/scp>\n                    Cyhalothrin\u2010induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-4492","authenticated-orcid":false,"given":"Mustafa","family":"Ileriturk","sequence":"first","affiliation":[{"name":"Department of Animal Science, Horasan Vocational College Ataturk University  Erzurum 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