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This study aimed to investigate the toxic effects of glyphosate\u2010based herbicide (GBH) on reproduction in mice exposed to 0 (control group), 50 (low\u2010dose group), 250 (middle\u2010dose group), and 500 (high\u2010dose group) mg\/kg\/day GBH for 30\u2009days. Toxicological parameters, metabolomics, and transcriptomics were performed to reveal GBH\u2010induced reproductive toxicity. Our findings demonstrated that GBH exposure damaged mitochondrial pyknosis and the nuclear membrane of spermatogonia. GBH triggered a significant increase in sperm malformations in the high\u2010dose group. Omics data showed that GBH impaired the Krebs cycle and respiratory chain, blocked pyruvate metabolism and glycolysis\/gluconeogenesis, and influenced the pentose phosphate pathway and nucleotide synthesis and metabolism. Overall, the multi\u2010omics results revealed systematic and comprehensive evidence of the adverse effects of GBH exposure, providing new insights into the reproductive toxicity of organophosphorus pesticides.<\/jats:p>","DOI":"10.1002\/tox.23808","type":"journal-article","created":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T15:08:57Z","timestamp":1682262537000},"page":"1811-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated metabolomics and transcriptomics reveal glyphosate based\u2010herbicide induced reproductive toxicity through disturbing energy and nucleotide metabolism in mice testes"],"prefix":"10.1002","volume":"38","author":[{"given":"Lei","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College Qiqihar Medical University  Qiqihar Heilongjiang 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