{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:45:50Z","timestamp":1768733150242,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["NSTC 111\u20102320\u2010B\u2010040\u2010027"],"award-info":[{"award-number":["NSTC 111\u20102320\u2010B\u2010040\u2010027"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005007","name":"Asia University","doi-asserted-by":"publisher","award":["10933007"],"award-info":[{"award-number":["10933007"]}],"id":[{"id":"10.13039\/501100005007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial hypertrophy plays a crucial role in cardiovascular disease (CVD) development. Myocardial hypertrophy is an adaptive response by myocardial cells to stress after cardiac injury to maintain cardiac output and function. Angiotensin II (Ang\u2010II) regulates CVD through the renin\u2010angiotensin\u2010aldosterone system, and its signaling in cardiac myocytes leads to excessive reactive oxygen species (ROS) production, oxidative stress, and inflammation. Sesamin (SA), a natural compound in sesame seeds, has anti\u2010inflammatory and anti\u2010apoptotic effects. This study investigated whether SA could attenuate hypertrophic damage and oxidative injuries in H9c2 cells under Ang\u2010II stimulation. We found that SA decreased the cell surface area. Furthermore, Ang\u2010II treatment reduced Ang\u2010II\u2010increased ANP, BNP, and \u03b2\u2010MHC expression. Ang\u2010II enhanced NADPH oxidase activity, ROS formation, and decreased Superoxide Dismutase (SOD) activity. SA treatment reduces Ang\u2010II\u2010caused oxidative injuries. We also found that SA mitigates Ang\u2010II\u2010induced apoptosis and pro\u2010inflammatory responses. In conclusion, SA could attenuate Ang\u2010II\u2010induced cardiac hypertrophic injuries by inhibiting oxidative stress, apoptosis, and inflammation in H9c2 cells. Therefore, SA might be a potential supplement for CVD management.<\/jats:p>","DOI":"10.1002\/tox.23853","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T09:41:54Z","timestamp":1687772514000},"page":"2165-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sesamin suppresses <scp>angiotensin\u2010II<\/scp>\u2010enhanced oxidative stress and hypertrophic markers in H9c2 cells"],"prefix":"10.1002","volume":"38","author":[{"given":"Chih\u2010Chia","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Radiation Therapy and Oncology Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital  Chia\u2010Yi Taiwan"},{"name":"Department of Medical Laboratory and Biotechnology Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Ching","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department 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Medical University  Taichung Taiwan"},{"name":"Department of Medical Education Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-8349","authenticated-orcid":false,"given":"Shin\u2010Da","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Graduate Institute of Rehabilitation Science China Medical University  Taichung Taiwan"},{"name":"Department of Physical Therapy Asia University  Taichung 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