{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:37:14Z","timestamp":1781005034589,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073582"],"award-info":[{"award-number":["82073582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703266"],"award-info":[{"award-number":["81703266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803278"],"award-info":[{"award-number":["81803278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010950"],"award-info":[{"award-number":["2021A1515010950"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydroquinone (HQ) is an important metabolites of benzene in the body, and it has been found to result in cellular DNA damage, mutation, cell cycle imbalance, and malignant transformation. The JNK1 signaling pathway plays an important role in DNA damage repair. In this study, we focused on whether the JNK1 signaling pathway is involved in the HQ\u2010induced cell cycle abnormalities and the underlying mechanism. The results showed that HQ induced abnormal progression of the cell cycle and initiated the JNK1 signaling pathway. We further confirmed that JNK1 suppression decelerated the cell cycle progression through inhibiting pRb\/E2F1 signaling pathway and triggering p53\/p21 pathway. Therefore, we concluded that JNK1 might be involved in HQ\u2010induced malignant transformation associated with activating pRb\/E2F1 and inhibiting p53\/p21 signaling pathway which resulting in accelerating the cell cycle progression.<\/jats:p>","DOI":"10.1002\/tox.23870","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T17:23:58Z","timestamp":1687627438000},"page":"2344-2351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>JNK1<\/scp>\n                    activated\n                    <scp>pRb<\/scp>\n                    \/\n                    <scp>E2F1<\/scp>\n                    and inhibited p53\/p21 signaling pathway is involved in hydroquinone\u2010induced pathway malignant transformation of\n                    <scp>TK6<\/scp>\n                    cells by accelerating the cell cycle progression"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5422-6181","authenticated-orcid":false,"given":"Lingxue","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"},{"name":"Faculty of Medicine Macau University of Science and Technology  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheming","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-2103","authenticated-orcid":false,"given":"Huanwen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"},{"name":"The First Dongguan Affiliated Hospital Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.780"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2006.06.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29591"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100736"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-013-9247-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.08.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23155"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711404037"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304935200"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.121848"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10948"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209181200"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092121"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.5.607"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204383"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2016.04.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.v26.i1.60"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104518"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.139162"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109679"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113259"},{"issue":"2","key":"e_1_2_9_24_1","first-page":"716","article-title":"Taraxastane inhibits the proliferation, migration and invasion of human cervical cancer by inducing ROS\u2010mediated necrosis like cell death, cell cycle arrest and modulation of JNK\/MAPK signaling pathway","volume":"25","author":"Hu J","year":"2020","journal-title":"J BUON"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7010030"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1063-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.01.019"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:23:02Z","timestamp":1764307382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,22]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/tox.23870"],"URL":"https:\/\/doi.org\/10.1002\/tox.23870","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,22]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}