{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:27:12Z","timestamp":1790126832404,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder characterized by restrictive and repetitive behavior followed by impairment in social, verbal, and non\u2010verbal interaction and communication. Valproic acid (VPA) is a well\u2010known anti\u2010epileptic drug, but its prenatal exposure to animals causes social impairment, neurotransmitters imbalance, and neuroinflammation with ASD\u2010like phenotypes. Syringic acid (SA) is a polyphenolic compound with anti\u2010inflammatory, anti\u2010apoptotic, antioxidant, and neuromodulator activity. The purpose of study was to investigate the protective effect of Syringic acid (SA) in prenatal VPA\u2010treated rats through behavioral, neuroinflammation, oxidative stress, neurotransmitters, neuronal integrity, and apoptotic marker. Single dose of VPA was administered 600\u2009mg\/kg,\n                    <jats:italic>i.p.<\/jats:italic>\n                    on a gestational day (GD) 12th and SA was administrated from PnD 26th to 54th at the dose of 25, 50, and 100\u2009mg\/kg,\n                    <jats:italic>p.o.<\/jats:italic>\n                    On PnD 56th behavioral parameters (Pain sensitivity, open field test, narrow beam walks test and social impairment test) were performed and all animals were sacrificed, and brain tissue was isolated for oxidative stress (GSH, CAT, and LPO), neuroinflammation (TNF\u2010\u03b1 and IL\u20106) and neurotransmitters (GABA and Glutamate), histopathology (H&amp;E, Nissl), immunohistochemistry (p38 MAPK) analysis. Rat treated with SA dose\u2010dependently prevented behavioral alteration, restored antioxidant enzymes, neurotransmitters level, decreased neuroinflammatory markers, and improved neuronal integrity. Furthermore, immunohistochemistry confirmed the reduced p38 MAPK marker expression by SA in VPA induced autistic behavior.\n                  <\/jats:p>","DOI":"10.1002\/tox.23876","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:30:42Z","timestamp":1687757442000},"page":"2400-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen\u2010activated protein kinase: Possible molecular approach"],"prefix":"10.1002","volume":"38","author":[{"given":"Sudhanshu","family":"Mallan","sequence":"first","affiliation":[{"name":"Neuropharmacology division, Department of Pharmacology ISF College of Pharmacy  Moga India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-6632","authenticated-orcid":false,"given":"Shamsher","family":"Singh","sequence":"additional","affiliation":[{"name":"Neuropharmacology division, Department of Pharmacology ISF College of Pharmacy  Moga India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118381953.ch51"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031816-044318"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.01.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.03.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2013.09.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.09.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.01.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1644"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.08.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36250"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.02.041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12070571"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9053-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21252"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-012-9354-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.069"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8297984"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2019.11.030"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.047"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomag.2014.02.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8535-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0575-x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.053"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.10.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0990667"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90267-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104296"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2018-0026"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.12.024"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579409990265"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1723401"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0717-1"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.02.003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12947"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147251"},{"key":"e_1_2_11_40_1","first-page":"179","volume-title":"International Review of Research in Developmental Disabilities","author":"Staples KL","year":"2012"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy043"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.22"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3074"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2741\/3250"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2019.05.006"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492113"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00672"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.08.025"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.02.005"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.030734"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00878-3"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0176-3"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.11.018"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.10.032"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-14-00170.1"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2017.1349227"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01329A"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328211"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:22:59Z","timestamp":1764307379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/tox.23876"],"URL":"https:\/\/doi.org\/10.1002\/tox.23876","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}