{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:58Z","timestamp":1791821158941,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1904154"],"award-info":[{"award-number":["U1904154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273927"],"award-info":[{"award-number":["82273927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The environmental pollutant bisphenol A (BPA), used in the manufacture of plastic packaging materials for various diets, is widely distributed in the environment and causes severe hepatotoxicity by inducing oxidative stress.\n                    <jats:italic>Artemisia argyi<\/jats:italic>\n                    essential oil (AAEO), a volatile oil component isolated from\n                    <jats:italic>Artemisia argyi H.L\u00e9v<\/jats:italic>\n                    . &amp;\n                    <jats:italic>Vaniot<\/jats:italic>\n                    , has pharmacological effects, especially for hepatoprotective actions. However, the potential effect of AAEO in BPA induced hepatotoxicity has not been characterized. First, we analyzed the chemical composition in AAEO by gas chromatography\u2013mass spectrometry. Herein, we investigated the effect of AAEO on hepatic metabolic changes in mice exposed to BPA. Results showed that compared with the BPA group, AAEO could reduce the level of liver function enzymes in BPA mice serum, and ameliorate hepatic lesions and fibrosis. Additionally, 20 differential metabolites screened by metabolomics were mainly involved in the reprogramming of glutathione metabolism, purine metabolism, and polyunsaturated fatty acid synthesis. Moreover, AAEO could reduce hepatic ferroptosis induced by BPA, as demonstrated by reducing xanthine oxidase activity, up\u2010regulating the activities of glutathione peroxidase 4 (GPX4), superoxide dismutase, and catalase and the expression of SLC7A11 to promote the glutathione synthetic, while inhibiting transferrin receptor 1 (TFR1) expression to reduce the accumulation of Fe\n                    <jats:sup>2+<\/jats:sup>\n                    in cells. Therefore, our study identified AAEO as a hepatic protectant against BPA\u2010induced hepatotoxicity by reversing the occurrence of ferroptosis.\n                  <\/jats:p>","DOI":"10.1002\/tox.23877","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T17:30:54Z","timestamp":1687627854000},"page":"2416-2428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatoprotective effect of\n                    <i>Artemisia Argyi<\/i>\n                    essential oil on bisphenol A\u2010induced hepatotoxicity via inhibition of ferroptosis in mice"],"prefix":"10.1002","volume":"38","author":[{"given":"Weiqi","family":"Cui","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China; School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 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