{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:37:48Z","timestamp":1778323068957,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:00:00Z","timestamp":1692489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Excess iodine will trigger the occurrence of autoimmune thyroiditis (AIT), and programmed death\u20101 (PD\u20101)\/programmed death ligand (PD\u2010L) will also contribute to the development of AIT. The purpose of this study was to explore the role that negative regulatory signals mediated by PD\u20101\/PD\u2010L play in the development of spontaneous autoimmune thyroiditis (SAT) in NOD.H\u20102h4 mice when they are exposed to iodine. Programmed death ligand 1 (PD\u2010L1) antibody was administered intraperitoneally to NOD.H\u20102h4 mice. The relevant indicators were determined by flow cytometry, real\u2010time quantitative polymerase chain reaction, enzyme\u2010linked immunosorbent assay, immunohistochemistry, pathological hematoxylin and eosin staining, and arsenic\u2013cerium catalytic spectrophotometry. Results showed that the level of urinary iodine, the level of thyroid lymphocyte infiltration, the level of thyroglobulin antibodies (TgAb) and interferon (IFN\u2010\u03b3)\/tumor necrosis factor (TNF\u2010\u03b1)\/interleukin (IL\u20102)\/IL\u201017, and the relative expression of PD\u20101\/PD\u2010L1\/programmed death\u20102 (PD\u2010L2) increased with the intervention of excess iodine. After the intervention of the PD\u2010L1 antibody, the expression of PD\u20101\/PD\u2010L1\/PD\u2010L2 in different degrees was inhibited, but the level of thyroid lymphocyte infiltration and serum TgAb\/IFN\u2010\u03b3\/TNF\u2010\u03b1\/ IL\u20102\/IL\u201017 did not decrease. Collectively, although PD\u20101\/PD\u2010L participates in the occurrence of SAT and induces inflammation, administration of the PD\u2010L1 antibody does not effectively improve the pathological process of SAT. More research is needed to determine whether PD\u20101\/PD\u2010L intervention can treat autoimmune thyroid disease.<\/jats:p>","DOI":"10.1002\/tox.23893","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:10:02Z","timestamp":1692681002000},"page":"2574-2584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A study of programmed death\u20101\/programmed death ligand and iodine\u2010induced autoimmune thyroiditis in\n                    <scp>NOD.H\u20102h4<\/scp>\n                    mice"],"prefix":"10.1002","volume":"38","author":[{"given":"Fan","family":"Li","sequence":"first","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"},{"name":"Control Infection Department Xi'an First Hospital  Xi'an People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Jin","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"He","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxuan","family":"Ren","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-6990","authenticated-orcid":false,"given":"Lixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention Harbin Medical University  Harbin People's Republic of China"},{"name":"National Health Commission &amp; Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology Harbin Medical University  Harbin People's Republic of China"},{"name":"Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21997"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22320"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21811"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22762"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22405"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0613"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.014"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12949"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.05.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0221"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.04.038"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/979167"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23671"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.0305"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1233576"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608873113"},{"issue":"10","key":"e_1_2_11_20_1","first-page":"79","article-title":"Expression level and mechanism of action of PD\u20101 in CD4+ and CD8+ T cells in Graves\u2019 disease","volume":"49","author":"Han H","year":"2020","journal-title":"J Med Res"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9540-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090331"},{"key":"e_1_2_11_23_1","first-page":"414","article-title":"Expression of PD\u2010L2 molecule in peripheral blood monocytes of patients with systemic lupus erythematosus and its clinical significance","volume":"33","author":"Wu PP","year":"2017","journal-title":"Chin J Immunol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/406136"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.10.025"},{"issue":"3","key":"e_1_2_11_26_1","first-page":"352","article-title":"Changes in PD\u20101 expression levels of peripheral blood CD8+ T cells in patients with autoimmune hepatitis","volume":"20","author":"Rui ZL","year":"2017","journal-title":"J Pract Liver Dis"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.002"},{"key":"e_1_2_11_28_1","first-page":"664","article-title":"Research progress on the role of PD\u20101\/PD\u2010L1 in autoimmune diseases","volume":"50","author":"He HX","year":"2021","journal-title":"J Huazhong Univ Sci Technol"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.031"},{"key":"e_1_2_11_30_1","first-page":"541","article-title":"Progress of PD\u20101 pathway regulating lymphocyte differentiation involved in autoimmune disease development","volume":"22","author":"Zheng ZQ","year":"2016","journal-title":"J Tianjin Med Univ"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4156"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010592"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-111"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:23:39Z","timestamp":1762608219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,20]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/tox.23893"],"URL":"https:\/\/doi.org\/10.1002\/tox.23893","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,20]]},"assertion":[{"value":"2022-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}