{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:40:09Z","timestamp":1793461209716,"version":"4.5.0"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was administered at a dose of 30\u2009mg\/kg\/bw for 7\u2009days to induce testicular toxicity in rats. Oral doses of 5 and 10\u2009mg\/kg\/bw SNP were administered to rats for 7\u2009days after PbAc administration. According to our findings, while PbAc administration increased MDA content in rats, it decreased GPx, SOD, CAT activity and GSH content. NF\u2010kB, IL\u20101\u03b2, TNF\u2010\u03b1, and COX\u20102, which are among the inflammation parameters that increased due to PbAc, decreased with the administration of SNP. Nrf2, HO\u20101, and NQO1 mRNA transcript levels decreased with PbAc, but SNP treatments increased these mRNA levels in a dose\u2010dependent manner. RAGE and NLRP3 gene expression were upregulated in PbAc treated rats. MAPK14, MAPK15, and JNK relative mRNA levels decreased with SNP treatment in PbAc treated rats. While the levels of apoptosis markers Bax, Caspase\u20103, and Apaf\u20101 increased in rats treated with PbAc, the level of Bcl\u20102 decreased, but SNP inhibited this apoptosis markers. PbAc caused histopathological deterioration in testis tissue and negatively affected spermatogenesis. When the sperm quality was examined, the decrease in sperm motility and spermatozoon density caused by PbAc, and the increase in the ratio of dead and abnormal spermatozoa were inhibited by SNP. As a result, while PbAc increased apoptosis and inflammation by inducing oxidative stress in testicles, SNP treatment inhibited these changes and increased sperm quality.<\/jats:p>","DOI":"10.1002\/tox.23900","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T15:44:52Z","timestamp":1689867892000},"page":"2656-2667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effects of sinapic acid on lead acetate\u2010induced oxidative stress, apoptosis and inflammation in testicular tissue"],"prefix":"10.1002","volume":"38","author":[{"given":"Sibel \u00c7i\u011fdem","family":"Tuncer","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-6540","authenticated-orcid":false,"given":"Serkan Ali","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-5515","authenticated-orcid":false,"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7858","authenticated-orcid":false,"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-021-06948-z","article-title":"Evaluation of oxidative stress, inflammation, apoptosis, oxidative DNA damage and metalloproteinases in the lungs of rats treated with cadmium and carvacrol","volume":"49","author":"Yesildag K","year":"2022","journal-title":"Mol Biol Rep"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10010132"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-07611-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22130"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23312"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02268-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.03.068"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-7278(199912)14:5<439::AID-TOX1>3.0.CO;2-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20530"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20722"},{"key":"e_1_2_9_12_1","first-page":"446","volume-title":"Handbook on the Toxicology of Metals","author":"Nordberg G","year":"2011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21994"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05805-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22058"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22547"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23321"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23137"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23744"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21901"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2256(1998)13:1<43::AID-TOX2>3.0.CO;2-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22281"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics8040094"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199417000028"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13593"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2012.01322.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13600"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"336","article-title":"Clomiphene citrate ameliorated lead acetate\u2010induced reproductive toxicity in male Wistar rats","volume":"23","author":"Wahab OA","year":"2019","journal-title":"JBRA Assist Reprod"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-06099-6"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00380-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2019.11.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16050659"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23784"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22634"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.12.016"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.111411"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-018-1006-6"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.33808\/clinexphealthsci.864015"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v8i10.2225"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf403092b"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111163"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3571614","article-title":"Sinapic acid and its derivatives as medicine in oxidative stress\u2010induced diseases and aging","volume":"2016","author":"Chen C","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.622815"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0033-6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27134139"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14117"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14369"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22384"},{"key":"e_1_2_9_50_1","first-page":"248","article-title":"Determination of enzyme activity in lipid peroxidation and glutathione pathways","volume":"15","author":"Matkovics B","year":"1988","journal-title":"Laboratoriumi Diagnosztika"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_9_52_1","first-page":"673","article-title":"Methods of enzymatic analysis","author":"Catalase AH","year":"1974","journal-title":"Elsevier"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13524"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12553"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.5152\/VetSciPract.2022.221118"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23762"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20431"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20639"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20666"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21976"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.10124"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22545"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211059821"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119730"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21928"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2018.12.006"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115591373"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13047"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00095-x"},{"issue":"5","key":"e_1_2_9_74_1","first-page":"803","article-title":"Enhanced RAGE expression in the dorsal root ganglion may contribute to neuropathic pain induced by spinal nerve ligation in rats","volume":"17","author":"Li X","year":"2016","journal-title":"Pain Med"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109232"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108369"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134882"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145239"},{"key":"e_1_2_9_79_1","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-023-08286-8","article-title":"Morin ameliorates methotrexate\u2010induced hepatotoxicity via targeting Nrf2\/HO\u20101 and Bax\/Bcl2\/Caspase\u20103 signaling pathways","volume":"50","author":"K\u0131z\u0131l HE","year":"2023","journal-title":"Mol Biol Rep"},{"issue":"2","key":"e_1_2_9_80_1","first-page":"167","article-title":"Beneficial effects of silymarin and naringin against methotrexate\u2010induced hepatotoxicity in rats","volume":"12","author":"Kandemir F","year":"2017","journal-title":"Vet Sci Pract"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14049-4"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07395-0"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid587.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2014.10.010"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23162"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2311"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800843"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2019.09.005"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.067"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233714548474"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1358-2"},{"issue":"10","key":"e_1_2_9_92_1","first-page":"634","article-title":"Meta analysis for effect of lead on male productive function","volume":"24","author":"Xu H\u2010h","year":"2006","journal-title":"Chinese J Ind Hygiene Occup Dis"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14547"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-15240-3"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.23900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:23:21Z","timestamp":1762608201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.23900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":93,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/tox.23900"],"URL":"https:\/\/doi.org\/10.1002\/tox.23900","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]},"assertion":[{"value":"2023-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}