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The response of overdose and illegal abuse of cyclizine includes confusion, tremors, chest pain, ataxia, seizures, and lead to suicide. Macrophage plays the important role in the innate immunity. However, over activation of macrophages results in pro\u2010inflammatory responses in peripheral tissues. In the present study, cyclizine was found to enhanced the generation of pro\u2010inflammatory cytokines, including tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, and IL\u20106. We further found that secretion of nitrogen oxide (NO) induced by cyclizine via expression of inducible nitric oxide synthases (iNOS). Cyclizine exhibited parallel stimulation of phosphorylation of nuclear factor\u2010\u03baB (NF\u03baB) p65, and its up\u2010stream factor Akt. These results indicated that the expression of pro\u2010inflammatory cytokines, pro\u2010inflammatory mediators, and adhesion molecules would be induced by cyclizine via activation of Akt\u2010NF\u03baB pathway in macrophages.<\/jats:p>","DOI":"10.1002\/tox.23913","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:01:54Z","timestamp":1691492514000},"page":"2819-2825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Cyclizine\u2010induced<\/scp> proinflammatory responses through <scp>Akt\u2010NF\u03baB<\/scp> pathway in macrophages"],"prefix":"10.1002","volume":"38","author":[{"given":"Hao\u2010Min","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology Kaohsiung Armed Forces General Hospital  Kaohsiung City 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