{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:10:18Z","timestamp":1747152618396,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous studies have indicated enrichment of circular RNA (circRNA) in the brain takes on a momentous role in cerebral ischemia\u2010reperfusion (CIR) injury. A recent study discovered a novel circCRIM1, was highly expressed in the middle cerebral artery occlusion\u2010reperfusion (MCAO\/R) model. Nevertheless, its specific biological function remained unknown. The study was to explore circCRIM1 in CIR\u2010induced neuronal apoptosis. As measured, circCRIM1 and TXNIP were up\u2010regulated, while miR\u2010141\u20103p was down\u2010regulated in MCAO\/R mouse model and OGD\/R SH\u2010SY5Y cells. Depleting circCRIM1 reduced the number of apoptotic neurons in MCAO\/R rats, increased the number of Nissl bodies, prevented reactive oxygen species production and oxidative stress imbalance in brain tissues, repressed cleaved caspase\u20103, Bax, and Cyto C protein levels and increased Bcl\u20102 levels. Overexpression of circCRIM1 further repressed neuronal activity and accelerated apoptosis in OGD\/R model, disrupted redox balance. Depleting circCRIM1 had the opposite effect in OGD\/R model. Knocking down miR\u2010141\u20103p or TXNIP weakened the effects of knocking down circCRIM1 or overexpressing circCRIM1, separately. Mechanistically, circCRIM1 exerted an active role in CIR injury via miR\u2010141\u20103p to mediate TXNIP. All in all, the circCRIM1\/miR\u2010141\u20103p\/TXNIP axis might be a latent therapeutic target for CIR injury.<\/jats:p>","DOI":"10.1002\/tox.23916","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T12:36:05Z","timestamp":1691757365000},"page":"2845-2856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CircCRIM1<\/scp>\/<scp>microRNA<\/scp>\u2010141\u20103p\/thioredoxin\u2010binding protein axis mediates neuronal apoptosis after cerebral ischemia\u2010reperfusion"],"prefix":"10.1002","volume":"38","author":[{"given":"Teng","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurological Intervention Dalian Municipal Central Hospital  Dalian City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurological Intervention Dalian Municipal Central Hospital  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