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However, it has not attracted considerable attention. In this study, an obese mouse model was established using an HFD, and the reproductive function of male mice was evaluated after intragastric administration of 100\u2009\u03bcL of a 10\u2009mg\/mL PS\u2010NP suspension for 4\u2009weeks. By determining the morphology and vitality of sperm and related indicators of testosterone production, it was found that PS\u2010NPs aggravated the destruction of sperm mitochondrial structure, decrease sperm activity, and testosterone production in HFD\u2010fed mice. To comprehensively analyze the injury mechanism, the integrity of the blood testicular barrier (BTB) and the function of Leydig and Sertoli cells were further analyzed. It was found that PS\u2010NPs could destroy BTB, promote the degeneration of Leydig cells, reduce the number of Sertoli cells, and decrease lactate secretion in HFD\u2010fed mice. PS\u2010NPs further interfered with redox homeostasis in the testicular tissues of HFD\u2010fed mice. This study found that PS\u2010NPs could aggravate the damage to the reproductive system of obese male mice by further perturbing its redox homeostasis and revealed the potential health risk of PS\u2010NPs exposure under an HFD.<\/jats:p>","DOI":"10.1002\/tox.23923","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T14:11:20Z","timestamp":1691590280000},"page":"2881-2893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis"],"prefix":"10.1002","volume":"38","author":[{"given":"Peirong","family":"Cai","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University  Yangzhou Jiangsu China"},{"name":"Joint International Research Laboratory of Agriculture and Agri\u2010Product Safety of the Ministry of Education of China Yangzhou 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