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H. Ohashi (Leguminosae) also called as \u201cEvergreen shrub\u201d and <jats:italic>Artemisia argyi<\/jats:italic> H.L\u00e9v. and Vaniot (Compositae) also named as \u201cChinese mugwort\u201d those two\u2010leaf extracts frequently used as herbal medicine, especially in south east Asia and eastern Asia. Anthracyclines such as doxorubicin (DOX) are commonly used as effective chemotherapeutic drugs in anticancer therapy around the world. However, chemotherapy\u2010induced cardiotoxicity, dilated cardiomyopathy, and congestive heart failure are seen in patients who receive DOX therapy, with the mechanisms underlying DOX\u2010induced cardiac toxicity remaining unclear. Mitochondrial dysfunction, oxidative stress, inflammatory response, and cardiomyocytes have been shown to play crucial roles in DOX\u2010induced cardiotoxicity. Isoliquiritigenin (ISL, 10\u2009mg\/kg) is a bioactive flavonoid compound with protective effects against inflammation, neurodegeneration, cancer, and diabetes. Here, in this study, our aim is to find out the <jats:italic>Artemisia argyi<\/jats:italic> (AA) and <jats:italic>Ohwia caudata<\/jats:italic> (OC) leaf extract combination with Isoliquiritigenin in potentiating and complementing effect against chemo drug side effect to ameliorate cardiac damage and improve the cardiac function. In this study, we showed that a combination of low (AA 300\u2009mg\/kg; OC 100\u2009mg\/kg) and high\u2010dose(AA 600\u2009mg\/kg; OC 300\u2009mg\/kg) AA and OC water extract with ISL activated the cell survival\u2010related AKT\/PI3K signaling pathway in DOX\u2010treated cardiac tissue leading to the upregulation of the antioxidant markers SOD, HO\u20101, and Keap\u20101 and regulated mitochondrial dysfunction through the Nrf2 signaling pathway. Moreover, the water extract of AA and OC with ISL inhibited the inflammatory response genes <jats:italic>IL<\/jats:italic>\u2010<jats:italic>6<\/jats:italic> and <jats:italic>IL<\/jats:italic>\u2010<jats:italic>1\u03b2<\/jats:italic>, possibly through the NF\u03baB\/AKT\/PI3K\/p38\u03b1\/NRLP3 signaling pathways. The water extract of AA and OC with ISL could be a potential herbal drug treatment for cardiac hypertrophy, inflammatory disease, and apoptosis, which can lead to sudden heart failure.<\/jats:p>","DOI":"10.1002\/tox.23936","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:22:55Z","timestamp":1693812175000},"page":"3026-3042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A combination of isoliquiritigenin with <scp><i>Artemisia argyi<\/i><\/scp> and <scp><i>Ohwia caudata<\/i><\/scp> water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2\/Ho\u20101 signaling pathways in <scp>SD<\/scp> rats with doxorubicin\u2010induced acute cardiotoxicity"],"prefix":"10.1002","volume":"38","author":[{"given":"Dennis jine","family":"Yuan Hsieh","sequence":"first","affiliation":[{"name":"School of Medical Laboratory and Biotechnology Chung Shan Medical University  Taichung Taiwan"},{"name":"Clinical Laboratory Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-9412","authenticated-orcid":false,"given":"Md. 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