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We investigated the effect of taurine on AgNPs\u2010induced reproductive toxicity in male rats. The animals were intraperitoneally injected with AgNPs (200\u2009\u03bcg\/kg) alone or co\u2010administered with taurine at 50 and 100\u2009mg\/kg for 21 successive days. Exogenous taurine administration significantly abated AgNPs\u2010induced oxidative injury by decreasing the levels of oxidative stress indices while boosting antioxidant enzymes activities and glutathione level in the hypothalamus, testes and epididymis of exposed animals. Taurine administration alleviated AgNPs\u2010induced inflammatory response and caspase\u20103 activity, an apoptotic biomarker. Moreover, taurine significantly improved spermiogram, reproductive hormones and the marker enzymes of testicular function in AgNPs\u2010treated animals. The ameliorative effect of taurine on pathological lesions induced by AgNPs in the exposed animals was substantiated by histopathological data. This study provides the first mechanistic evidence that taurine supplementation affords therapeutic effect against reproductive dysfunction associated with AgNPs exposure in male rats.<\/jats:p>","DOI":"10.1002\/tox.23945","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:40:41Z","timestamp":1693230041000},"page":"61-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exogenous taurine administration abates reproductive dysfunction in male rats exposed to silver nanoparticles"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-178X","authenticated-orcid":false,"given":"Isaac A.","family":"Adedara","sequence":"first","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan  Ibadan 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