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This study aimed to explore the effects of calcitriol on macrophages and cancer cells in the TME and its impact on gastric cancer cell proliferation and cisplatin resistance. In vitro TME models were established using conditioned medium from gastric cancer cells (CCM) and macrophages (MCM) treated with or without calcitriol. The results revealed that calcitriol treatment suppressed the expression of glycolysis\u2010related genes and proteins (GLUT1, HKII, LDHA) in MCM\u2010induced gastric cancer cells, leading to increased cancer cell apoptosis and reduced viability, along with decreased Cyclin D1 gene expression. Moreover, calcitriol treatment inhibited mTOR activation in MCM\u2010induced gastric cancer cells. Additionally, calcitriol hindered CCM\u2010induced M2 macrophage polarization by reducing CD206 expression and increasing TNF\u03b1 gene expression in THP1\u2010derived macrophages, attenuating cisplatin resistance. These findings suggest that calcitriol may impede gastric cancer progression by targeting glycolysis and M2 macrophage polarization through the regulation of mTOR activation in the TME.<\/jats:p>","DOI":"10.1002\/tox.23975","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T17:19:00Z","timestamp":1696439940000},"page":"830-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RETRACTED: Calcitriol suppresses gastric cancer progression and cisplatin resistance by inhibiting glycolysis and <scp>M2<\/scp> macrophage polarization through inhibition of <scp>mTOR<\/scp> activation"],"prefix":"10.1002","volume":"39","author":[{"given":"Li","family":"Jie","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Naval Medical University  Shanghai 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