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Before examining how curcumin influenced rats' liver fibrosis when thioacetamide (TAA) was produced, the current study employed nanoparticles (NPs) to improve curcumin bioavailability. Sixty mature rats were separated into six groups (Group 1, control; Group 2, curcumin; Group 3, curcumin nanoparticles; Group 4, TAA; Group 5, TAA\u2009+\u2009curcumin; Group 6, TAA\u2009+\u2009curcumin NPs). TAA administration caused considerable increases in serum liver enzymes associated with a remarkable depletion in the levels of albumin and total protein relative to the control. In addition, a significant elevation in malonaldehyde (MDA) level with a significant depletion in the antioxidant enzymes activity was detected. Also, TAA had a significant effect on the inflammation markers represented by the elevation in tumor necrosis factor (TNF\u03b1) and DNA damage. Administration of curcumin or curcumin NPs in TAA\u2010intoxicated rats significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) alleviates liver injury by correcting antioxidant status, inflammatory markers, and oxidative stress. The results of comparing TAA\u2010intoxicated rats treated with curcumin NPs to TAA\u2010intoxicated rats treated with bulk curcumin revealed that the ameliorative effect of nanocurcumin was stronger. These observations concluded that nanoparticle formulation can increase curcumin bioavailability and solubility, enhancing its antioxidant and anti\u2010inflammatory efficiency, resulting in greater potential against thioacetamide\u2010induced hepatotoxicity in rats.<\/jats:p>","DOI":"10.1002\/tox.23984","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:59:24Z","timestamp":1696269564000},"page":"388-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effectiveness of curcumin nanoparticles in rat liver fibrosis caused by thioacetamide"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-8283","authenticated-orcid":false,"given":"Aliaa M.","family":"Radwan","sequence":"first","affiliation":[{"name":"Biochemistry Division, Chemistry Department, Faculty of Science Tanta University  Tanta 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