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Se and ACR treatments were applied for 10\u2009days. On the 11th day of the experimental study, intracardiac blood samples from the rats were taken under anesthesia and euthanized. Sperm motility and morphology were evaluated. Dihydrotestosterone, FSH, and LH levels in sera were analyzed with commercial ELISA kits. MDA, GSH, TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 levels and SOD, GPx, and CAT, activities were measured to detect the level of oxidative stress and inflammation in rat testis tissues. Expression analysis of HSD17B1, StAR, CYP17A1, MAPk14, and P\u201053 as target mRNA levels were performed with Real Time\u2010PCR System technology for each cDNA sample synthesized from rat testis RNA. Testicular tissues were evaluated by histopathological, immunohistochemical, and immunofluorescent examinations. Serum dihydrotestosterone and FSH levels decreased significantly in the ACR group compared to the control group, while LH levels increased and a high dose of Se prevented these changes caused by ACR. A high dose of Se prevented these changes caused by ACR. ACR\u2010induced testicular oxidative stress, inflammation, apoptosis, changes in the expression of reproductive enzymes, some changes in sperm motility and morphology, DNA, and tissue damage, and Se administration prevented these pathologies caused by ACR. As a result of this study, it was determined that Se prevents oxidative stress, inflammation, apoptosis, autophagy, and DNA damage in testicular toxicity induced by ACR in rats.<\/jats:p>","DOI":"10.1002\/tox.23996","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:18:44Z","timestamp":1700662724000},"page":"1402-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Selenium reduces acrylamide\u2010induced testicular toxicity in rats by regulating\n                    <scp>HSD17B1<\/scp>\n                    ,\n                    <scp>StAR<\/scp>\n                    , and\n                    <scp>CYP17A1<\/scp>\n                    expression, oxidative stress, inflammation, apoptosis, autophagy, and\n                    <scp>DNA<\/scp>\n                    damage"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-3367","authenticated-orcid":false,"given":"Serkan","family":"Yildirim","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-1816","authenticated-orcid":false,"given":"Emin","family":"Sengul","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"},{"name":"Department of Pharmacology, Faculty of Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1591-684X","authenticated-orcid":false,"given":"Emrah Hicazi","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Andrology, Faculty of Veterinary Medicine Kastamonu University  Kastamonu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-2556","authenticated-orcid":false,"given":"\u0130rfan","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine Kastamonu University  Kastamonu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-1262","authenticated-orcid":false,"given":"Volkan","family":"Gelen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Kafkas University  Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-6720","authenticated-orcid":false,"given":"Samet","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-7485","authenticated-orcid":false,"given":"Yusuf","family":"Dag","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum 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