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An antidepressant Agomelatine which is a melatonin receptor (MT1\/MT2) agonist and serotonin receptor (5\u2010HT2C) antagonist has been reported by studies to have antioxidant and anti\u2010inflammatory effects. In our study, we aimed to detect the effects of citrate\u2010coated silver nanoparticle\u2010loaded agomelatine application on neurodegeneration, endoplasmic reticulum stress, autophagic and apoptotic cell death, inflammation, and P2X7R expression in the cerebral ischemia\u2013reperfusion model to facilitate the passage of blood\u2013brain barrier. Forty two Sprague\u2013Dawley rats in total were divided into six equal groups (n:7) and applications were performed. Acute cerebral injury in the ischemia\u2013reperfusion model was created 2\u2009h after internal carotid artery ligation in rats and then at the 2nd hour of reperfusion citrate\u2010coated silver nanoparticles loaded with Agomelatine were applied. Twenty four hours later, neurologic analysis on animals in experimental groups was performed, animals were decapitated and GSH, GPx, SOD, CAT, MDA, IL\u20101\u03b2, and TNF\u2010\u03b1 parameters were examined after taking blood and the cerebral tissue samples. As a result, it was determined that ischemia\u2013reperfusion caused endoplasmic reticulum stress in the cerebral tissues and thus caused cellular injury.<\/jats:p>","DOI":"10.1002\/tox.24021","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T18:52:10Z","timestamp":1701111130000},"page":"1531-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Citrate\u2010coated silver nanoparticles loaded with agomelatine provide neuronal therapy in acute cerebral ischemia\/reperfusion of rats by inhibiting the oxidative stress, endoplasmic reticulum stress, and\n                    <scp>P2X7<\/scp>\n                    receptor\u2010mediated inflammasome"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-1262","authenticated-orcid":false,"given":"Volkan","family":"Gelen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of 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