{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:03:07Z","timestamp":1790190187750,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, it was aimed to investigate the effects of berberine (BER) and curcumin (CUR) in the experimental model of cystitis induced by cyclophosphamide (CYP). A total of 36 Wistar\u2010Albino female rats were used in the study. Rats were randomly divided into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096). Normal control group, dimethyl sulfoxide (DMSO) group, CYP group (75\u2009mg\/kg), CYP\u2009+\u2009BER (75\u2009mg\/kg CYP and 50\u2009mg\/kg BER), CYP\u2009+\u2009CUR group (75\u2009mg\/kg CYP and 50\u2009mg\/kg CUR), CYP\u2009+\u2009BER\u2009+\u2009CUR group (75\u2009mg\/kg CYP and 50\u2009mg\/kg BER and 50\u2009mg\/kg CUR). Severe edema, hyperemia, hemorrhage, necrosis, and thinning of the epithelial layer were observed in the CYP group. BER and CUR treatment significantly reduced these pathologies. Masson\u2010Trichrome staining was severe in the CYP group and moderate in the CYP\u2009+\u2009BER, CYP\u2009+\u2009CUR, and CYP\u2009+\u2009BER\u2009+\u2009CUR groups. In the CYP group, there was a severe expression of caspase\u20103, TNF\u2010\u03b1 and IL\u20106, and mild expression of IL\u201010. BER and CUR treatment decreased the expression of caspase\u20103, TNF\u2010\u03b1, and IL\u20106 and increased the expression of IL\u201010. The findings of the study reveal that BER and CUR treatments may reduce CYP\u2010induced bladder damage by reducing apoptosis and inflammation and ameliorating histopathological changes.\n                  <\/jats:p>","DOI":"10.1002\/tox.24025","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T06:35:05Z","timestamp":1699857305000},"page":"1315-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Uroprotective effects of berberine and curcumin in cyclophosphamide\u2010induced interstitial cystitis"],"prefix":"10.1002","volume":"39","author":[{"given":"Murat","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-5168","authenticated-orcid":false,"given":"Fikret","family":"Alt\u0131nda\u011f","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13118"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287211398255"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4364-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.06.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.088"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13985"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2815-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117590"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27053"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3152-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.11.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01305"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.736030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1552244"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.10.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-018-0409-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2017.02.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12110713"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2016.1140406"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.08.016"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02182-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.10.008"},{"key":"e_1_2_10_24_1","first-page":"1","article-title":"If you assume, you can make an ass out of u and me: a decade of the disector for stereological counting of particles in 3D space","volume":"188","author":"Mayhew TM","year":"1996","journal-title":"J Anat"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2012.07.008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112443"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-019-0724-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.05.029"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2008.05.010"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00341"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11137"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.09.049"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21494"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.24025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:45:48Z","timestamp":1762591548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.24025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/tox.24025"],"URL":"https:\/\/doi.org\/10.1002\/tox.24025","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"2023-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}