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Triggering microglia activation and neuroinflammation is deemed an early event resulting in PD. However, the underlying pathogenesis of PD by PQ is not clear yet. In this article, C57BL\/6J mice treated with PQ could successfully act out Parkinson\u2010like. In addition, we observed the fluorescence intensity enhancement of Iba\u20101 activated microglia with released pro\u2010inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. Surprisingly, the injection of minocycline before PQ for many hours not only can effectively improve the neurobehavioral symptoms of mice but inhibit the activation of microglia and the release of pro\u2010inflammatory substances, even controlling the gradual damage and loss of neurons. A further mechanism of minocycline hampered the expression levels of key signaling proteins PI3K, PDK1, p\u2010AKT, and CD11b (the receptor of microglia membrane recognition), while a large number of inflammatory factors. Our results suggested that the CD11b\/PI3K\/NOX2 pathway may be a clue that microglia\u2010mediated inflammatory responses and neuronal damage in a PQ\u2010induced abnormal behavior Parkinson\u2010like mouse.<\/jats:p>","DOI":"10.1002\/tox.24053","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T09:31:34Z","timestamp":1704706294000},"page":"1874-1888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5941-525X","authenticated-orcid":false,"given":"Ge","family":"Shi","sequence":"first","affiliation":[{"name":"School of Public Health Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Key Laboratory of Environmental Factors and Chronic Disease Control School 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